| Vitamin D3 is not effective in the treatment of chronic chilblains. | |
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MedLine Citation:
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PMID: 19196366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Chronic chilblains is a common disease causing major restrictions in daily life, nevertheless little is known about effective treatment. In a literature search, we found thin evidence of three interventions: fluocinolone cream, nifedipine and vitamin D3. OBJECTIVE: We have conducted a study to assess the effect of oral administration of 2000 IU vitamin D3 per day on patients suffering from chronic chilblains. METHODS: The study was based on a self-controlled design. The study population consisted of patients with a confirmed diagnosis. Outcome measurement was the change in severity of the complaints and disability. We checked for interference by temperature and other confounders. LIMITATIONS: The size of the cohort (n = 33) was a limitation. RESULTS: After correction for confounding factors, 19% of the subjects reported fewer complaints and 6% fewer disability, in both the placebo and vitamin D3 treatment groups. CONCLUSION: Oral administration of 2000 IU vitamin D3 per day is not better than placebo in the treatment of patients with chronic chilblains. |
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Authors:
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I H Souwer; A L M Lagro-Janssen |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of clinical practice Volume: 63 ISSN: 1742-1241 ISO Abbreviation: Int. J. Clin. Pract. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-02-06 Completed Date: 2010-01-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9712381 Medline TA: Int J Clin Pract Country: England |
Other Details:
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Languages: eng Pagination: 282-6 Citation Subset: IM |
Affiliation:
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i.souwer@wxs.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Chilblains / drug therapy* Cholecalciferol / therapeutic use* Chronic Disease Female Humans Male Middle Aged Patient Compliance Treatment Failure Vitamins / therapeutic use* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Vitamins; 67-97-0/Cholecalciferol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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