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Vitamin D3: an ever green molecule .
MedLine Citation:
PMID:  23277049     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Vitamin D3 is a key regulator of vertebrates homeostasis. It is synthesized from the precursor 7-dehydrocholesterol upon UVB exposure in the skin and then hydrolyzed in the liver in position 25, to be finally converted into its active form, 1,25-dihydroxyvitamin D (1,25(OH)2D or calcitriol), in the kidneys. The biological activity of this molecule depends on its binding to the nuclear receptor VDR, which binds VDRE once complexed with RXR-alpha. Despite being present in different types of food, the best way to assume it at physiological levels remains the exposure to UVB radiation at certain hours of the day and at particular angles of the Earth's crust. There is plenty of evidence that altered levels of vitamin D3 are associated with pathological conditions, such as osteoporosis, cancer, immunological and infectious diseases. In this review, we discuss vitamin D3 metabolism, its role in several diseases and the link between vitamin D3 and immune cells.
Authors:
Michele Di Rosa; Lucia Malaguarnera; Anna Nicolosi; Cristina Sanfilippo; Clorinda Mazzarino; Piero Pavone; Massimiliano Berretta; Stefano Cosentino; Bruno Cacopardo; Marilia Rita Pinzone; Giuseppe Nunnari
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Publication Detail:
Type:  Journal Article     Date:  2013-01-01
Journal Detail:
Title:  Frontiers in bioscience (Scholar edition)     Volume:  5     ISSN:  1945-0524     ISO Abbreviation:  Front Biosci (Schol Ed)     Publication Date:  2013  
Date Detail:
Created Date:  2013-01-01     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101485241     Medline TA:  Front Biosci (Schol Ed)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  247-60     Citation Subset:  IM    
Affiliation:
Department of Biomedical Sciences, University of Catania, via Androne 83, 95124, Catania, Italy.
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