| Vitamin D supplementation reduces insulin resistance in South Asian women living in New Zealand who are insulin resistant and vitamin D deficient - a randomised, placebo-controlled trial. | |
| | |
MedLine Citation:
|
PMID: 19781131 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Low serum 25-hydroxyvitamin D (25(OH)D) has been shown to correlate with increased risk of type 2 diabetes. Small, observational studies suggest an action for vitamin D in improving insulin sensitivity and/or insulin secretion. The objective of the present study was to investigate the effect of improved vitamin D status on insulin resistance (IR), utilising randomised, controlled, double-blind intervention administering 100 microg (4000 IU) vitamin D(3) (n 42) or placebo (n 39) daily for 6 months to South Asian women, aged 23-68 years, living in Auckland, New Zealand. Subjects were insulin resistant - homeostasis model assessment 1 (HOMA1)>1.93 and had serum 25(OH)D concentration < 50 nmol/l. Exclusion criteria included diabetes medication and vitamin D supplementation >25 microg (1000 IU)/d. The HOMA2 computer model was used to calculate outcomes. Median (25th, 75th percentiles) serum 25(OH)D(3) increased significantly from 21 (11, 40) to 75 (55, 84) nmol/l with supplementation. Significant improvements were seen in insulin sensitivity and IR (P = 0.003 and 0.02, respectively), and fasting insulin decreased (P = 0.02) with supplementation compared with placebo. There was no change in C-peptide with supplementation. IR was most improved when endpoint serum 25(OH)D reached > or = 80 nmol/l. Secondary outcome variables (lipid profile and high sensitivity C-reactive protein) were not affected by supplementation. In conclusion, improving vitamin D status in insulin resistant women resulted in improved IR and sensitivity, but no change in insulin secretion. Optimal vitamin D concentrations for reducing IR were shown to be 80-119 nmol/l, providing further evidence for an increase in the recommended adequate levels. Registered Trial No. ACTRN12607000642482. |
| | |
Authors:
|
Pamela R von Hurst; Welma Stonehouse; Jane Coad |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-09-28 |
Journal Detail:
|
Title: The British journal of nutrition Volume: 103 ISSN: 1475-2662 ISO Abbreviation: Br. J. Nutr. Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-02-03 Completed Date: 2010-03-04 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372547 Medline TA: Br J Nutr Country: England |
Other Details:
|
Languages: eng Pagination: 549-55 Citation Subset: IM |
Affiliation:
|
Institute of Food, Nutrition and Human Health, Massey University, Private Bag 102 904, North Shore Mail Centre, Auckland, New Zealand. p.r.vonhurst@massey.ac.nz |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Asia / ethnology Asian Continental Ancestry Group C-Reactive Protein / metabolism Cholecalciferol / administration & dosage, pharmacology, therapeutic use* Dietary Supplements Double-Blind Method Female Humans Insulin / secretion* Insulin Resistance* / ethnology Middle Aged New Zealand Nutritional Status Vitamin D / analogs & derivatives*, blood Vitamin D Deficiency / blood, drug therapy*, ethnology Vitamins / pharmacology, therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
0/Vitamins; 11061-68-0/Insulin; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D; 67-97-0/Cholecalciferol; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Relative expression of antigen B coding gene of bubaline isolates of Echinococcus granulosus in fert...
Next Document: Assessing physical activity in general practice: a disconnect between clinical practice and public h...