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Vitamin D supplementation in renal disease: is calcitriol all that is needed?
MedLine Citation:
PMID:  22536772     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Vitamin D not only plays important roles in mineral metabolism, but also affects the risk of mortality and cardiovascular events. Since the kidney is the main organ that produces 1,25-dihydroxyvitamin D, active vitamin D sterols are widely used in patients with chronic kidney disease (CKD), especially those with secondary hyperparathyroidism. CKD patients also have higher risk of vitamin D deficiency, due to urinary loss associated with proteinuria and possible down-regulation of megalin in the proximal tubular cells. Accordingly, it is reasonable to supplement nutritional vitamin D in CKD patients with vitamin D deficiency. Although still unclear, it has been suggested that local 1α-hydroxylase activity plays more significant roles in CKD patients compared to those with normal kidney function. Future studies should examine whether correction of vitamin D deficiency, administration of active vitamin D, or both, provides survival benefits in patients with CKD.
Authors:
Masafumi Fukagawa; Hirotaka Komaba; Takayuki Hamano
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation. Supplementum     Volume:  243     ISSN:  0085-591X     ISO Abbreviation:  Scand. J. Clin. Lab. Invest. Suppl.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-04-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2984789R     Medline TA:  Scand J Clin Lab Invest Suppl     Country:  England    
Other Details:
Languages:  eng     Pagination:  120-3     Citation Subset:  IM    
Affiliation:
Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Isehara, Japan. fukagawa@tokai-u.jp
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