| Vitamin D supplementation in renal disease: is calcitriol all that is needed? | |
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MedLine Citation:
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PMID: 22536772 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Vitamin D not only plays important roles in mineral metabolism, but also affects the risk of mortality and cardiovascular events. Since the kidney is the main organ that produces 1,25-dihydroxyvitamin D, active vitamin D sterols are widely used in patients with chronic kidney disease (CKD), especially those with secondary hyperparathyroidism. CKD patients also have higher risk of vitamin D deficiency, due to urinary loss associated with proteinuria and possible down-regulation of megalin in the proximal tubular cells. Accordingly, it is reasonable to supplement nutritional vitamin D in CKD patients with vitamin D deficiency. Although still unclear, it has been suggested that local 1α-hydroxylase activity plays more significant roles in CKD patients compared to those with normal kidney function. Future studies should examine whether correction of vitamin D deficiency, administration of active vitamin D, or both, provides survival benefits in patients with CKD. |
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Authors:
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Masafumi Fukagawa; Hirotaka Komaba; Takayuki Hamano |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of clinical and laboratory investigation. Supplementum Volume: 243 ISSN: 0085-591X ISO Abbreviation: Scand. J. Clin. Lab. Invest. Suppl. Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-04-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984789R Medline TA: Scand J Clin Lab Invest Suppl Country: England |
Other Details:
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Languages: eng Pagination: 120-3 Citation Subset: IM |
Affiliation:
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Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, Isehara, Japan. fukagawa@tokai-u.jp |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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