Document Detail

Vitamin D supplementation in renal disease: is calcitriol all that is needed?
MedLine Citation:
PMID:  22536772     Owner:  NLM     Status:  MEDLINE    
Vitamin D not only plays important roles in mineral metabolism, but also affects the risk of mortality and cardiovascular events. Since the kidney is the main organ that produces 1,25-dihydroxyvitamin D, active vitamin D sterols are widely used in patients with chronic kidney disease (CKD), especially those with secondary hyperparathyroidism. CKD patients also have higher risk of vitamin D deficiency, due to urinary loss associated with proteinuria and possible down-regulation of megalin in the proximal tubular cells. Accordingly, it is reasonable to supplement nutritional vitamin D in CKD patients with vitamin D deficiency. Although still unclear, it has been suggested that local 1α-hydroxylase activity plays more significant roles in CKD patients compared to those with normal kidney function. Future studies should examine whether correction of vitamin D deficiency, administration of active vitamin D, or both, provides survival benefits in patients with CKD.
Masafumi Fukagawa; Hirotaka Komaba; Takayuki Hamano
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation. Supplementum     Volume:  243     ISSN:  0085-591X     ISO Abbreviation:  Scand. J. Clin. Lab. Invest. Suppl.     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-27     Completed Date:  2012-08-20     Revised Date:  2014-08-04    
Medline Journal Info:
Nlm Unique ID:  2984789R     Medline TA:  Scand J Clin Lab Invest Suppl     Country:  England    
Other Details:
Languages:  eng     Pagination:  120-3     Citation Subset:  IM    
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MeSH Terms
Calcitriol / therapeutic use*
Chronic Disease
Dietary Supplements*
Kidney Diseases / complications,  metabolism*
Vitamin D / administration & dosage*,  metabolism
Vitamin D Deficiency / etiology
Reg. No./Substance:
1406-16-2/Vitamin D; FXC9231JVH/Calcitriol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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