Document Detail

Vitamin D supplementation during exercise training does not alter inflammatory biomarkers in overweight and obese subjects.
MedLine Citation:
PMID:  22183086     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to examine the effects of vitamin D supplementation on inflammatory biomarkers in overweight and obese adults participating in a progressive resistance exercise training program. Twenty-three (26.1 ± 4.7 years) overweight and obese (BMI 31.3 ± 3.2 kg/m2) adults were randomized into a double-blind vitamin D supplementation (Vit D 4,000 IU/day; female 5, male 5) or placebo (PL, female 7; male 6) intervention trial. Both groups performed 12 weeks (3 days/week) of progressive resistance exercise training (three sets of eight exercises) at 70-80% of one repetition maximum. Whole-blood lipopolysaccharide (LPS)-stimulated tumor necrosis factor (TNF) α production as well as circulating C-reactive protein (CRP), TNFα, interleukin 6 (IL-6), and alanine aminotransferase (ALT) were assessed at baseline and after the 12-week intervention. No main effects of group or time were detected for circulating CRP, TNFα, IL-6, and ALT. As expected, when PL and Vit D groups were combined, there was a significant correlation between percent body fat and CRP at baseline (r = 0.45, P = 0.04), and between serum 25OHD and CRP at 12 weeks (r = 0.49, P = 0.03). The PL group had a significant increase in 25 μg/ml LPS + polymixin B-stimulated TNFα production (P = 0.04), and both groups had a significant reduction in unstimulated TNFα production (P < 0.05) after the 12-week intervention. Vitamin D supplementation in healthy, overweight, and obese adults participating in a resistance training intervention did not augment exercise-induced changes in inflammatory biomarkers.
Andres E Carrillo; Michael G Flynn; Catherine Pinkston; Melissa M Markofski; Yan Jiang; Shawn S Donkin; Dorothy Teegarden
Related Documents :
21904276 - Effect of maximal and slow versus recreational muscle contractions on energy expenditur...
22015326 - Effects of treadmill exercise and training frequency on anabolic signaling pathways in ...
16141746 - Cardiovascular adaptations to exercise training after uncomplicated acute myocardial in...
22039956 - Core temperature is a greater influence than endogenous 17β-estradiol on the exercise-...
3131476 - In vivo lactate kinetics at rest and during recovery from exhaustive exercise in coho s...
25428136 - Influence of running shoes and cross-trainers on achilles tendon forces during running ...
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2011-12-20
Journal Detail:
Title:  European journal of applied physiology     Volume:  112     ISSN:  1439-6327     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-13     Completed Date:  2012-11-29     Revised Date:  2013-08-15    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  3045-52     Citation Subset:  IM    
Wastl Human Performance Laboratory, Purdue University, West Lafayette, IN 47907, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Alanine Transaminase / blood
Analysis of Variance
Biological Markers / blood
C-Reactive Protein / metabolism
Combined Modality Therapy
Dietary Supplements*
Double-Blind Method
Inflammation Mediators / blood*
Interleukin-6 / blood
Obesity / blood,  immunology,  therapy*
Overweight / blood,  immunology,  therapy*
Resistance Training*
Time Factors
Treatment Outcome
Tumor Necrosis Factor-alpha / blood
Vitamin D / analogs & derivatives,  blood,  therapeutic use*
Young Adult
Grant Support
R25 CA128770-02/CA/NCI NIH HHS; R25CA128770/CA/NCI NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/IL6 protein, human; 0/Inflammation Mediators; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D; 9007-41-4/C-Reactive Protein; EC Transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Structure, function and selective inhibition of bacterial acetyl-coa carboxylase.
Next Document:  Pedaling time variability is increased in dropped riding position.