| Vitamin D supplementation during Antarctic winter. | |
| | |
MedLine Citation:
|
PMID: 19225122 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Persons with limited exposure to ultraviolet B light, including space travelers, may not receive enough vitamin D. Recent studies indicate that optimal serum 25-hydroxyvitamin D [25(OH)D] should be > or = 80 nmol/L. OBJECTIVE: This study was designed to evaluate the effectiveness of 3 doses of vitamin D to raise and maintain 25(OH)D to a concentration >80 nmol/L in persons with limited ultraviolet B light exposure. DESIGN: This was a 5-mo, prospective, randomized, double-blind study of vitamin D supplementation. It was conducted during winter in Antarctica at the McMurdo Station, when ultraviolet B radiation levels are essentially zero. The 55 subjects were randomly divided into 3 groups for vitamin D supplementation: 2000 IU/d (n = 18), 1000 IU/d (n = 19), and 400 IU/d (n = 18). An additional 7 subjects did not take supplements or took supplements of their own choosing. Blood samples were collected about every 2 mo during the winter. RESULTS: About 5 mo after supplementation started, 25(OH)D increased to 71 +/- 23 nmol/L in the 2000-IU/d group, 63 +/- 25 nmol/L in the 1000-IU/d group, and 57 +/- 15 nmol/L in the 400-IU/d group and decreased to 34 +/- 12 nmol/L in the group not taking supplements. CONCLUSIONS: These data will enable us to provide space crews with evidence-based recommendations for vitamin D supplementation. The findings also have implications for other persons with limited ultraviolet light exposure, including polar workers and the elderly. |
| | |
Authors:
|
Scott M Smith; Keri K Gardner; James Locke; Sara R Zwart |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-02-18 |
Journal Detail:
|
Title: The American journal of clinical nutrition Volume: 89 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2009 Apr |
Date Detail:
|
Created Date: 2009-03-19 Completed Date: 2009-04-06 Revised Date: 2009-05-15 |
Medline Journal Info:
|
Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 1092-8 Citation Subset: AIM; IM |
Affiliation:
|
Space Life Sciences Directorate, NASA Johnson Space Center, Houston, TX 77058, USA. scott.m.smith@nasa.gov |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Antarctic Regions Bone Density Conservation Agents / administration & dosage*, biosynthesis Diet* Dietary Supplements Dose-Response Relationship, Drug Double-Blind Method Female Humans Male Prospective Studies Seasons Sunlight* Vitamin D / administration & dosage*, analogs & derivatives*, biosynthesis, blood Vitamin D Deficiency / blood, prevention & control |
| Chemical | |
Reg. No./Substance:
|
0/Bone Density Conservation Agents; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Multiple micronutrient supplementation during early childhood increases child size at 2 y of age onl...
Next Document: Does the MTHFR 677C-->T variant affect the Recommended Dietary Allowance for folate in the US pop...