Document Detail


Vitamin D status of socio-economically deprived children in Kabul, Afghanistan.
MedLine Citation:
PMID:  18654949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Cultural, environmental, and diet-related factors were postulated to lead to a high prevalence of vitamin D deficiency in Kabul's socioeconomically deprived children under 5 years of age. We investigated the prevalence of plasma 25-hydroxyvitamin D (25-OHD) deficiency in such a group. METHODS: Children between 6 months and up to 5 years of age were randomly sampled in the Chindawal area of Kabul in January 2005. Plasma samples were frozen to below -20 degrees C and 25(OH)D3 concentrations estimated by high-pressure liquid chromatography. RESULTS: For all 107 children tested, the median plasma 25(OH)D concentration was 5 ng/mL with a range of 2-24 ng/mL; 73% had concentrations of < 8 ng/mL; 13 other samples were not analyzed due to insufficiency of plasma, staff, or technical problems. About 35 others approached either did not give consent or blood could not be obtained. CONCLUSIONS: This study was conducted in a high-risk population at a peak season for vitamin D deficiency. We conclude that this population of children living in Kabul to be at great risk of developing vitamin D deficiency, rickets, and other possible immunological effects of deficiency.
Authors:
Semira Manaseki-Holland; M Zulf Mughal; Zulfiqar Bhutta; M Qasem Shams
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition     Volume:  78     ISSN:  0300-9831     ISO Abbreviation:  Int J Vitam Nutr Res     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-07-25     Completed Date:  2008-10-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1273304     Medline TA:  Int J Vitam Nutr Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  16-20     Citation Subset:  IM    
Affiliation:
Department of Public Health and Epidemiology, Birmingham University, Edgbaston, Birmingham, UK. semira.manasekiholland@akdn-afg.org
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MeSH Terms
Descriptor/Qualifier:
Afghanistan / epidemiology
Child, Preschool
Chromatography, High Pressure Liquid / statistics & numerical data
Female
Humans
Infant
Male
Nutritional Status*
Poverty / statistics & numerical data*
Prevalence
Risk Factors
Socioeconomic Factors
Urban Population / statistics & numerical data
Vitamin D / analogs & derivatives,  blood*
Vitamin D Deficiency / blood,  epidemiology*
Grant Support
ID/Acronym/Agency:
//Wellcome Trust
Chemical
Reg. No./Substance:
1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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