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Vitamin D status and metabolic syndrome in Asian Indians.
MedLine Citation:
PMID:  21060309     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
In this study, we aimed to estimate serum 25-hydroxy vitamin D (25-OH-D) in Asian Indians and test for association between 25-OH-D levels, insulin resistance (IR) and metabolic syndrome (MS). Serum 25-OH-D was measured in a cross-sectional sample of 441 Indians, aged 39.7±12.8 years (237 men and 204 women) with 27.9% prevalence of MS. Vitamin D insufficiency (12.5 to <50 nmol l(-1)) and hypovitaminosis D (50 to <100 nmol l(-1)) were present in 65.6 and 31.1% of participants, respectively. The 25-OH-D levels did not differ significantly between sexes (P=0.057). Multivariate regression analysis indicated a positive relationship between 25-OH-D and β-cell function (homeostasis model assessment (HOMA)-B; β=0.245, P=0.006), whereas regression coefficients for fasting glucose (β=0.262, P=0.794), insulin (β=-0.140, P=0.889) and HOMA-IR (β=-0.119, P=0.172) were insignificant. Sex-stratified analysis showed no linear trend for increasing quintiles of 25-OH-D with prevalence of MS or its components (P>0.05). Although highly prevalent, vitamin D insufficient status was not associated with MS or IR in Asian Indians of either sex.
Authors:
V Majumdar; D Nagaraja; R Christopher
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Publication Detail:
Type:  Journal Article     Date:  2010-11-09
Journal Detail:
Title:  International journal of obesity (2005)     Volume:  35     ISSN:  1476-5497     ISO Abbreviation:  Int J Obes (Lond)     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101256108     Medline TA:  Int J Obes (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  1131-4     Citation Subset:  IM    
Affiliation:
Department of Neurochemistry, National Institute of Mental Health and Neuro Sciences, Bangalore, India.
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