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Vitamin D status in pediatric patients with a history of malignancy.
MedLine Citation:
PMID:  23037871     Owner:  NLM     Status:  Publisher    
Background:Multiple studies associate low vitamin D levels with cancer morbidity and mortality. However, few studies measured vitamin D in pediatric patients with malignancy. Our aim was to assess vitamin D status in a large cohort of pediatric cancer patients and define risk factors for deficiency.Methods:Circulating 25-hydroxyvitamin D (25OHD) was measured in 211 patients. Calcium intake and sun exposure habits were assessed in 142 patients (aged 12.1±5.8y, Male=69, mean time from diagnosis 4.4±3.8y).Results:Daily calcium intake was 66.2±39.3% of the recommended daily allowance (RDA). Mean 25OHD levels were 20.6±7.9ng/ml. Vitamin D deficiency (<15ng/ml) was found in 24.6% of the patients, and insufficiency (15-20ng/ml) in 23.2%. Younger age and amount of sun exposure were associated with higher serum 25OHD. No association was found with calcium intake, disease type, gender, BMI-standard deviation score, years since diagnosis, or undergoing stem cell transplantation. 25OHD levels during winter were significantly lower than summer levels.Conclusion:The prevalence of vitamin D deficiency and insufficiency in pediatric patients with a history of malignancy was high, while calcium intake was low. These findings are concerning given the risk for osteoporosis in this population and the possible role of vitamin D in the context of malignancy.Pediatric Research (2012); doi:10.1038/pr.2012.131.
Dalit Modan-Moses; Orit Pinhas-Hamiel; Dafna Munitz-Shenkar; Vered Temam; Hannah Kanety; Amos Toren
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-04
Journal Detail:
Title:  Pediatric research     Volume:  -     ISSN:  1530-0447     ISO Abbreviation:  Pediatr. Res.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
1] Pediatric Endcrinology Unit, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan 52621, Israel [2] Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel.
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