| Vitamin D status in pediatric patients with a history of malignancy. | |
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MedLine Citation:
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PMID: 23037871 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background:Multiple studies associate low vitamin D levels with cancer morbidity and mortality. However, few studies measured vitamin D in pediatric patients with malignancy. Our aim was to assess vitamin D status in a large cohort of pediatric cancer patients and define risk factors for deficiency.Methods:Circulating 25-hydroxyvitamin D (25OHD) was measured in 211 patients. Calcium intake and sun exposure habits were assessed in 142 patients (aged 12.1±5.8y, Male=69, mean time from diagnosis 4.4±3.8y).Results:Daily calcium intake was 66.2±39.3% of the recommended daily allowance (RDA). Mean 25OHD levels were 20.6±7.9ng/ml. Vitamin D deficiency (<15ng/ml) was found in 24.6% of the patients, and insufficiency (15-20ng/ml) in 23.2%. Younger age and amount of sun exposure were associated with higher serum 25OHD. No association was found with calcium intake, disease type, gender, BMI-standard deviation score, years since diagnosis, or undergoing stem cell transplantation. 25OHD levels during winter were significantly lower than summer levels.Conclusion:The prevalence of vitamin D deficiency and insufficiency in pediatric patients with a history of malignancy was high, while calcium intake was low. These findings are concerning given the risk for osteoporosis in this population and the possible role of vitamin D in the context of malignancy.Pediatric Research (2012); doi:10.1038/pr.2012.131. |
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Authors:
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Dalit Modan-Moses; Orit Pinhas-Hamiel; Dafna Munitz-Shenkar; Vered Temam; Hannah Kanety; Amos Toren |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-04 |
Journal Detail:
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Title: Pediatric research Volume: - ISSN: 1530-0447 ISO Abbreviation: Pediatr. Res. Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-5 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1] Pediatric Endcrinology Unit, Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Tel-Hashomer, Ramat-Gan 52621, Israel [2] Sackler School of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel. |
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