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Vitamin D status during normal pregnancy and postpartum. A longitudinal study in 141 Danish women.
MedLine Citation:
PMID:  22098305     Owner:  NLM     Status:  Publisher    
Abstract Background/objectives: To assess vitamin D status during normal pregnancy and in the postpartum lactation period. Subjects/methods: The study comprised 141 healthy, ethnic Danish women with normal pregnancies, who were residents in Greater Copenhagen. Serum 25-hydroxy-vitamin D(2)+D(3) (25-OH-vitamin D) was measured at 18, 32 and 39 weeks' gestation and 8 weeks postpartum. Results: There was a significant increase in 25-OH-vitamin D from 18 to 32 weeks' gestation (P=0.0001) followed by a significant decrease from 32 to 39 weeks (P=0.001) as well as from 39 weeks to 8 weeks postpartum (P<0.0001). At 18, 32, 39 weeks' gestation and 8 weeks postpartum, median 25-OH-vitamin D values were 77, 98, 91, and 73 nmol/L, respectively. During pregnancy and postpartum, none of the women displayed severe vitamin D deficiency (values <13 nmol/L). Between 1.4% and 4.3% of the participants displayed moderate vitamin D deficiency (values 13-24 nmol/L), 16-19% displayed vitamin D insufficiency (values 25-50 nmol/L), 77-84% had values >50 nmol/L and 0.7-2.8% had values >200 nmol/L. Conclusions: Low vitamin D status is frequent among pregnant Danish women, especially in late pregnancy and during lactation. Median dietary intake of vitamin D in women of reproductive age was 2.4 μg/day (10-90 percentile range=1.4-5.0). The recommendations for vitamin D supplementation prior to conception, during pregnancy and lactation should be reconsidered.
Nils Milman; Anne-Mette Hvas; Thomas Bergholt
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-18
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  -     ISSN:  1619-3997     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Obstetrics and Gynecology, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
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