| Vitamin D status during normal pregnancy and postpartum. A longitudinal study in 141 Danish women. | |
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MedLine Citation:
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PMID: 22098305 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Background/objectives: To assess vitamin D status during normal pregnancy and in the postpartum lactation period. Subjects/methods: The study comprised 141 healthy, ethnic Danish women with normal pregnancies, who were residents in Greater Copenhagen. Serum 25-hydroxy-vitamin D(2)+D(3) (25-OH-vitamin D) was measured at 18, 32 and 39 weeks' gestation and 8 weeks postpartum. Results: There was a significant increase in 25-OH-vitamin D from 18 to 32 weeks' gestation (P=0.0001) followed by a significant decrease from 32 to 39 weeks (P=0.001) as well as from 39 weeks to 8 weeks postpartum (P<0.0001). At 18, 32, 39 weeks' gestation and 8 weeks postpartum, median 25-OH-vitamin D values were 77, 98, 91, and 73 nmol/L, respectively. During pregnancy and postpartum, none of the women displayed severe vitamin D deficiency (values <13 nmol/L). Between 1.4% and 4.3% of the participants displayed moderate vitamin D deficiency (values 13-24 nmol/L), 16-19% displayed vitamin D insufficiency (values 25-50 nmol/L), 77-84% had values >50 nmol/L and 0.7-2.8% had values >200 nmol/L. Conclusions: Low vitamin D status is frequent among pregnant Danish women, especially in late pregnancy and during lactation. Median dietary intake of vitamin D in women of reproductive age was 2.4 μg/day (10-90 percentile range=1.4-5.0). The recommendations for vitamin D supplementation prior to conception, during pregnancy and lactation should be reconsidered. |
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Authors:
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Nils Milman; Anne-Mette Hvas; Thomas Bergholt |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-18 |
Journal Detail:
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Title: Journal of perinatal medicine Volume: - ISSN: 1619-3997 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0361031 Medline TA: J Perinat Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Obstetrics and Gynecology, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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