| Vitamin D status and 5-year changes in urine albumin creatinine ratio and parathyroid hormone in a general population. | |
| | |
MedLine Citation:
|
PMID: 23377775 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Vitamin D is associated with cardiovascular disease and renal function but the mechanisms are as yet unexplained. Microalbuminuria is associated with a higher risk of kidney function loss, cardiovascular disease, and mortality. Parathyroid hormone is a predictor of cardiovascular mortality and negatively correlated with glomerular filtration rate. We investigated the association between vitamin D status and 5-year changes in urine albumin creatinine ratio (UACR) and parathyroid hormone (PTH). A random sample of 6,784 individuals aged 30-60 years from a general population participated in the Inter99 study in 1999-2001. Vitamin D (serum-25-hydroxyvitamin D) was measured at baseline by high-performance liquid chromatography. UACR and PTH were measured at baseline and follow-up. Increased UACR was defined as UACR >4.0 mg/g reflecting the upper quartile at baseline. We included 4,330 individuals who participated at 5-year follow-up. In multivariable linear regression analysis, a 10-nmol/l higher baseline level of vitamin D was associated with a 5-year decrease in UACR by 0.92 % (95 % confidence interval, CI 0.13, 1.71). In multivariable logistic regression analysis, the odds ratio of developing increased UACR during follow-up was 0.96 (95 % CI 0.92, 0.98) per 10 nmol/l higher baseline vitamin D level. We found a significant inverse cross-sectional (p < 0.0001) but no prospective association (p = 0.6) between baseline vitamin D status and parathyroid hormone. We found low vitamin D status to be a predictor of long-term development of increased UACR. It remains to be proven whether vitamin D deficiency is a causal and reversible factor in the development of albuminuria. |
| | |
Authors:
|
Tea Skaaby; Lise Lotte Nystrup Husemoen; Charlotta Pisinger; Torben Jørgensen; Betina Heinsbæk Thuesen; Knud Rasmussen; Mogens Fenger; Peter Rossing; Allan Linneberg |
Related Documents
:
|
12523945 - Ethnic differences in self-reported lack of access to a regular doctor: a population-ba... 20939145 - "killed by its mother": infanticide in providence county, rhode island, 1870 to 1938. 20851225 - Obstetrician-gynecologist physicians' beliefs about emergency contraception: a national... 23103035 - Vascular responses to long- and short-term exposure to fine particulate matter: mesa ai... 19056835 - Physical activity and television watching in relation to risk of type 2 diabetes: the b... 7976475 - Interest in natural family planning among female family practice patients. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-2-4 |
Journal Detail:
|
Title: Endocrine Volume: - ISSN: 1559-0100 ISO Abbreviation: Endocrine Publication Date: 2013 Feb |
Date Detail:
|
Created Date: 2013-2-4 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9434444 Medline TA: Endocrine Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Research Centre for Prevention and Health, Glostrup Hospital, Nordre Ringvej 57, 2600, Glostrup, Denmark, tea.skaaby.01@regionh.dk. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Characterization of particulate matter and its related metal toxicity in an urban location in South ...
Next Document: Bioaccumulation of Heavy Metals in Mollusca Species and Assessment of Potential Risks to Human Healt...