Document Detail

Vitamin D status and 5-year changes in urine albumin creatinine ratio and parathyroid hormone in a general population.
MedLine Citation:
PMID:  23377775     Owner:  NLM     Status:  Publisher    
Vitamin D is associated with cardiovascular disease and renal function but the mechanisms are as yet unexplained. Microalbuminuria is associated with a higher risk of kidney function loss, cardiovascular disease, and mortality. Parathyroid hormone is a predictor of cardiovascular mortality and negatively correlated with glomerular filtration rate. We investigated the association between vitamin D status and 5-year changes in urine albumin creatinine ratio (UACR) and parathyroid hormone (PTH). A random sample of 6,784 individuals aged 30-60 years from a general population participated in the Inter99 study in 1999-2001. Vitamin D (serum-25-hydroxyvitamin D) was measured at baseline by high-performance liquid chromatography. UACR and PTH were measured at baseline and follow-up. Increased UACR was defined as UACR >4.0 mg/g reflecting the upper quartile at baseline. We included 4,330 individuals who participated at 5-year follow-up. In multivariable linear regression analysis, a 10-nmol/l higher baseline level of vitamin D was associated with a 5-year decrease in UACR by 0.92 % (95 % confidence interval, CI 0.13, 1.71). In multivariable logistic regression analysis, the odds ratio of developing increased UACR during follow-up was 0.96 (95 % CI 0.92, 0.98) per 10 nmol/l higher baseline vitamin D level. We found a significant inverse cross-sectional (p < 0.0001) but no prospective association (p = 0.6) between baseline vitamin D status and parathyroid hormone. We found low vitamin D status to be a predictor of long-term development of increased UACR. It remains to be proven whether vitamin D deficiency is a causal and reversible factor in the development of albuminuria.
Tea Skaaby; Lise Lotte Nystrup Husemoen; Charlotta Pisinger; Torben Jørgensen; Betina Heinsbæk Thuesen; Knud Rasmussen; Mogens Fenger; Peter Rossing; Allan Linneberg
Related Documents :
22294785 - Assessment of a 'fast-track' referral service for intrauterine contraception following ...
23915585 - Gender differences in long-term survival of medicare beneficiaries undergoing mitral va...
22539655 - Persistent respiratory symptoms in clean-up workers 5 years after the prestige oil spill.
23211545 - Neonatal brachial plexus palsy with vaginal birth after cesarean: a case-control study.
24129265 - Alcohol intoxication and condom use self-efficacy effects on women's condom use intenti...
22182055 - Current and future medical treatments for menometrorrhagia during the premenopause.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-4
Journal Detail:
Title:  Endocrine     Volume:  -     ISSN:  1559-0100     ISO Abbreviation:  Endocrine     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434444     Medline TA:  Endocrine     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Research Centre for Prevention and Health, Glostrup Hospital, Nordre Ringvej 57, 2600, Glostrup, Denmark,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Characterization of particulate matter and its related metal toxicity in an urban location in South ...
Next Document:  Bioaccumulation of Heavy Metals in Mollusca Species and Assessment of Potential Risks to Human Healt...