| Vitamin D and the skin: Physiology and pathophysiology. | |
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MedLine Citation:
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PMID: 21845365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The keratinocytes of the skin are unique in being not only the primary source of vitamin D for the body, but in possessing both the enzymatic machinery to metabolize the vitamin D produced to active metabolites (in particular 1,25(OH)(2)D) and the vitamin D receptor (VDR) that enables the keratinocytes to respond to the 1,25(OH)(2)D thus generated. Numerous functions of the skin are regulated by vitamin D and/or its receptor. These include inhibition of proliferation, stimulation of differentiation including formation of the permeability barrier, promotion of innate immunity, regulation of the hair follicle cycle, and suppression of tumor formation. Regulation of these actions is exerted by a number of different coregulator complexes including the coactivators vitamin D receptor interacting protein (DRIP) complex also known as Mediator and the steroid receptor coactivator (SRC) family (of which SRC 2 and 3 are found in keratincytes), the inhibitor hairless (Hr), and β-catenin whose impact on VDR function is complex. Different coregulators appear to be involved in different VDR regulated functions. This review will examine the various functions of vitamin D and its receptor in the skin, and explore the mechanisms by which these functions are regulated. |
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Authors:
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Daniel D Bikle |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Reviews in endocrine & metabolic disorders Volume: 13 ISSN: 1573-2606 ISO Abbreviation: Rev Endocr Metab Disord Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-03-08 Completed Date: 2012-07-09 Revised Date: 2013-04-15 |
Medline Journal Info:
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Nlm Unique ID: 100940588 Medline TA: Rev Endocr Metab Disord Country: United States |
Other Details:
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Languages: eng Pagination: 3-19 Citation Subset: IM |
Affiliation:
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Veterans Affairs Medical Center/University of California, San Francisco, San Francisco, CA 94121, USA. daniel.bikle@ucsf.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / physiology Humans Keratinocytes / cytology, metabolism Skin / cytology, metabolism*, physiopathology Vitamin D / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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P01 AR39448/AR/NIAMS NIH HHS; R01 AR050023/AR/NIAMS NIH HHS; R01 AR050023/AR/NIAMS NIH HHS; R01 AR051930/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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1406-16-2/Vitamin D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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