Document Detail


Vitamin D and skeletal muscle strength and endurance in COPD.
MedLine Citation:
PMID:  22556020     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is not known whether vitamin D levels make a significant contribution to muscle dysfunction in chronic obstructive pulmonary disease (COPD). In 104 COPD patients (mean±sd forced expiratory volume in 1 s 44±22 % predicted) and 100 age- and sex-matched controls, serum 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)(2)D) and parathyroid hormone (PTH) levels were measured and related to quadriceps strength and endurance. In a subset of 26 patients and 13 controls, quadriceps biopsy was performed and mRNA expression of myogenic regulatory factors (mrf) and fibre-specific myosin heavy chains (MHC) was determined. COPD patients were weaker and less physically active than controls. 25(OH)D levels were similar in both groups (48.5±25.5 nmol·L(-1) COPD versus 55.4±28.3 nmol·L(-1) control, p=0.07) but PTH levels were significantly higher in patients (5.2±2.3 pmol·mL(-1) versus 4.4±2.0 pmol·L(-1), p=0.01). 1,25(OH)D was significantly correlated with strength in controls, but not in COPD patients and not with quadriceps endurance assessed using repetitive magnetic stimulation in COPD (n=35) or control (n=35) subjects. In controls, but not COPD patients, muscle biopsy analysis showed a negative relationship between 25(OH)D and MHCIIa expression (r(2)=0.5, p=0.01) and a positive relationship between mrf4 and MHCIIa expression (r(2)=0.5, p=0.009), and myogenic regulatory factor myf5 and MHCI expression (r(2)=0.72, p=0.004). In contrast with healthy controls, muscle strength is not associated with vitamin D levels in COPD, which may represent vitamin D resistance.
Authors:
Abigail S Jackson; Dinesh Shrikrishna; Julia L Kelly; Samuel V Kemp; Nicholas Hart; John Moxham; Michael I Polkey; Paul Kemp; Nicholas S Hopkinson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-05-03
Journal Detail:
Title:  The European respiratory journal     Volume:  41     ISSN:  1399-3003     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-01     Completed Date:  2013-07-30     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  309-16     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Aged
Algorithms
Biopsy
Calcifediol / blood*
Calcitriol / blood*
Case-Control Studies
Female
Humans
Male
Middle Aged
Multivariate Analysis
Muscle Strength*
Muscle, Skeletal / metabolism*
Myosin Heavy Chains / metabolism
Parathyroid Hormone / blood*
Pulmonary Disease, Chronic Obstructive / blood*,  metabolism
Grant Support
ID/Acronym/Agency:
G0701628//Medical Research Council
Chemical
Reg. No./Substance:
0/Parathyroid Hormone; EC 3.6.4.1/Myosin Heavy Chains; FXC9231JVH/Calcitriol; P6YZ13C99Q/Calcifediol
Comments/Corrections
Erratum In:
Eur Respir J. 2013 Apr;41(4):998
Note: Kemp, Samuel V [added]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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