| Vitamin D and pregnancy: An old problem revisited. | |
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MedLine Citation:
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PMID: 20832734 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vitamin D has historically been considered to play a role solely in bone and calcium metabolism. Human disease associations and basic physiological studies suggest that vitamin D deficiency is plausibly implicated in adverse health outcomes including mortality, malignancy, cardiovascular disease, immune functioning and glucose metabolism. There is considerable evidence that low maternal levels of 25 hydroxyvitamin D are associated with adverse outcomes for both mother and fetus in pregnancy as well as the neonate and child. Vitamin D deficiency during pregnancy has been linked with a number of maternal problems including infertility, preeclampsia, gestational diabetes and an increased rate of caesarean section. Likewise, for the child, there is an association with small size, impaired growth and skeletal problems in infancy, neonatal hypocalcaemia and seizures, and an increased risk of HIV transmission. Other childhood disease associations include type 1 diabetes and effects on immune tolerance. The optimal concentration of 25 hydroxyvitamin D is unknown and compounded by difficulties in defining the normal range. Whilst there is suggestive physiological evidence to support a causal role for many of the associations, whether vitamin D deficiency is a marker of poor health or the underlying aetiological problem is unclear. Randomised controlled trials of vitamin D supplementation with an appropriate assessment of a variety of health outcomes are required. |
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Authors:
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Helen Barrett; Aidan McElduff |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Best practice & research. Clinical endocrinology & metabolism Volume: 24 ISSN: 1532-1908 ISO Abbreviation: Best Pract. Res. Clin. Endocrinol. Metab. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-09-13 Completed Date: 2011-01-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101120682 Medline TA: Best Pract Res Clin Endocrinol Metab Country: Netherlands |
Other Details:
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Languages: eng Pagination: 527-39 Citation Subset: IM |
Copyright Information:
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2010. Published by Elsevier Ltd. |
Affiliation:
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Royal Brisbane and Womens' Hospital, Brisbane, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cholecalciferol
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administration & dosage,
biosynthesis,
blood,
physiology Diabetes Mellitus / prevention & control Diabetes, Gestational / etiology Female Humans Infant, Newborn Infant, Newborn, Diseases / etiology Lactation / physiology Muscle, Skeletal / drug effects Parathyroid Hormone / physiology Pre-Eclampsia / etiology Pregnancy Pregnancy Complications* Reference Values Skin / drug effects Vitamin D Deficiency / complications*, mortality |
| Chemical | |
Reg. No./Substance:
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0/Parathyroid Hormone; 67-97-0/Cholecalciferol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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