Document Detail


Vitamin D and the parenteral nutrition patient.
MedLine Citation:
PMID:  19874954     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vitamin D is a prohormone produced in the skin epidermis when irradiated with sunlight or ultraviolet light B. It is also absorbed from food or supplements. Vitamin D must be converted to 25-hydroxyvitamin D3 (circulating form) and finally to the hormone, 1a,25-dihydroxyvitamin D3, before it can function. This hormone acts through a single nuclear receptor. The details of these conversions and molecular biology of the action of vitamin D3 are summarized. The physiologic functions of vitamin D have been expanded beyond the mineralization of the skeleton to include modulation of the immune system, terminal differentiation in several tissues, suppression of malignant cells, and anabolic activity in the skeleton and in the renal-cardiovascular system. Epidemiologic studies have associated vitamin D deficiency with an increased risk of colorectal and breast cancers and an increased risk of autoimmune diseases, such as multiple sclerosis, type 1 diabetes, and cardiovascular events. Thus, vitamin D is essential not only for the skeleton but also many other organ systems. Recommendations for 25-hydroxyvitamin D3 levels for PN patients are presented.
Authors:
Hector F DeLuca
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Gastroenterology     Volume:  137     ISSN:  1528-0012     ISO Abbreviation:  Gastroenterology     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-30     Completed Date:  2010-01-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S79-91     Citation Subset:  AIM; IM    
Affiliation:
Department of Biochemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706-1544, USA. deluca@biochem.wisc.edu
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MeSH Terms
Descriptor/Qualifier:
Bone Density Conservation Agents / administration & dosage*,  metabolism
Bone Resorption / metabolism
Calcification, Physiologic
Calcium / metabolism
Endocrine System / metabolism
Health
Homeostasis
Humans
Malabsorption Syndromes / metabolism
Parenteral Nutrition*
Practice Guidelines as Topic
Receptors, Calcitriol / metabolism
Vitamin D / administration & dosage*,  metabolism
Chemical
Reg. No./Substance:
0/Bone Density Conservation Agents; 0/Receptors, Calcitriol; 1406-16-2/Vitamin D; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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