Document Detail


Vitamin D and multiple sclerosis: epidemiology, immunology, and genetics.
MedLine Citation:
PMID:  22547098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: This review provides a brief update of new research findings on the role of vitamin D in multiple sclerosis (MS).
RECENT FINDINGS: Evidence continues to accumulate supporting a protective role for vitamin D in MS risk and progression. Notable recent findings are that high 25-hydroxyvitamin D [25(OH)D] at the time of a first demyelinating event predicts a lower MS risk and a decreased risk of MS among offspring whose mothers had high predicted 25(OH)D levels. While a small vitamin D intervention study did not find an association between vitamin D and MS progression, this study had little statistical power, and larger trials will be needed to assess the therapeutic potential of vitamin D. Recent immunological studies also show modulation of the immune system by vitamin D that may be favorable for preventing or slowing the progression of MS. The demonstration that rare variants in CYP27B1, which encodes the enzyme that converts vitamin D to its active form, are strongly associated with MS risk supports a causal role of vitamin D deficiency as a risk factor for MS.
SUMMARY: Research on the nature of the association between vitamin D and MS risk and progression continues to progress; however, additional research on the timing and dose-response relationship will be crucial for designing future prevention and treatment trials.
Authors:
Kelly C Simon; Kassandra L Munger; Alberto Ascherio
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Current opinion in neurology     Volume:  25     ISSN:  1473-6551     ISO Abbreviation:  Curr. Opin. Neurol.     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-01     Completed Date:  2012-08-31     Revised Date:  2013-01-18    
Medline Journal Info:
Nlm Unique ID:  9319162     Medline TA:  Curr Opin Neurol     Country:  England    
Other Details:
Languages:  eng     Pagination:  246-51     Citation Subset:  IM    
Affiliation:
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA.
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MeSH Terms
Descriptor/Qualifier:
25-Hydroxyvitamin D3 1-alpha-Hydroxylase / genetics*
Disease Progression
Humans
Multiple Sclerosis / diet therapy*,  epidemiology*,  genetics,  immunology
Risk Factors
Vitamin D / therapeutic use*
Grant Support
ID/Acronym/Agency:
R01 NS046635/NS/NINDS NIH HHS; R01 NS071082/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
1406-16-2/Vitamin D; EC 1.14.-/25-Hydroxyvitamin D3 1-alpha-Hydroxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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