| Vitamin D and multiple sclerosis: epidemiology, immunology, and genetics. | |
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MedLine Citation:
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PMID: 22547098 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: This review provides a brief update of new research findings on the role of vitamin D in multiple sclerosis (MS). RECENT FINDINGS: Evidence continues to accumulate supporting a protective role for vitamin D in MS risk and progression. Notable recent findings are that high 25-hydroxyvitamin D [25(OH)D] at the time of a first demyelinating event predicts a lower MS risk and a decreased risk of MS among offspring whose mothers had high predicted 25(OH)D levels. While a small vitamin D intervention study did not find an association between vitamin D and MS progression, this study had little statistical power, and larger trials will be needed to assess the therapeutic potential of vitamin D. Recent immunological studies also show modulation of the immune system by vitamin D that may be favorable for preventing or slowing the progression of MS. The demonstration that rare variants in CYP27B1, which encodes the enzyme that converts vitamin D to its active form, are strongly associated with MS risk supports a causal role of vitamin D deficiency as a risk factor for MS. SUMMARY: Research on the nature of the association between vitamin D and MS risk and progression continues to progress; however, additional research on the timing and dose-response relationship will be crucial for designing future prevention and treatment trials. |
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Authors:
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Kelly C Simon; Kassandra L Munger; Alberto Ascherio |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Current opinion in neurology Volume: 25 ISSN: 1473-6551 ISO Abbreviation: Curr. Opin. Neurol. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-01 Completed Date: 2012-08-31 Revised Date: 2013-01-18 |
Medline Journal Info:
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Nlm Unique ID: 9319162 Medline TA: Curr Opin Neurol Country: England |
Other Details:
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Languages: eng Pagination: 246-51 Citation Subset: IM |
Affiliation:
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Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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25-Hydroxyvitamin D3 1-alpha-Hydroxylase
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genetics* Disease Progression Humans Multiple Sclerosis / diet therapy*, epidemiology*, genetics, immunology Risk Factors Vitamin D / therapeutic use* |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS046635/NS/NINDS NIH HHS; R01 NS071082/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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1406-16-2/Vitamin D; EC 1.14.-/25-Hydroxyvitamin D3 1-alpha-Hydroxylase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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