Document Detail


Vitamin D metabolism in mammary gland and breast cancer.
MedLine Citation:
PMID:  21669251     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1α,25-Dihydroxycholecalciferol (1,25D) mediates growth inhibition and terminal differentiation in mammary epithelial cells via interaction with the vitamin D receptor (VDR). This review focuses on the concept that cells in the mammary gland express the vitamin D metabolizing enzyme CYP27B1 which converts the circulating vitamin D metabolite 25D to the active metabolite 1,25D. In support of this concept, CYP27B1 is developmentally regulated in mouse mammary gland, with highest levels found during pregnancy and lactation. In addition, human mammary cells cultured from normal breast tissue express VDR, CYP27B1 and the megalin-cubilin complex that facilitates internalization of 25D complexed with the vitamin D binding protein. When incubated with physiological concentrations of 25D, human mammary cells synthesize 1,25D in sufficient quantities to mediate growth inhibition. However, emerging evidence suggests that deregulation of VDR and CYP27B1 occurs during cancer development and contributes to abrogation of the tumor suppressive effects triggered by 25D.
Authors:
JoEllen Welsh
Publication Detail:
Type:  Journal Article; Review     Date:  2011-06-12
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  347     ISSN:  1872-8057     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-10-24     Completed Date:  2012-06-11     Revised Date:  2014-01-13    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  55-60     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
25-Hydroxyvitamin D3 1-alpha-Hydroxylase / genetics,  metabolism
Animals
Breast Neoplasms / metabolism*
Calcitriol / biosynthesis,  physiology
Cell Line, Tumor
Cell Transformation, Neoplastic / metabolism
Female
Humans
Mammary Glands, Human / metabolism*
Mice
Receptors, Calcitriol / metabolism
Signal Transduction
Steroid Hydroxylases / genetics,  metabolism
Vitamin D / metabolism*
Chemical
Reg. No./Substance:
0/Receptors, Calcitriol; 1406-16-2/Vitamin D; EC 1.14.-/25-Hydroxyvitamin D3 1-alpha-Hydroxylase; EC 1.14.-/Steroid Hydroxylases; EC 1.14.13.126/vitamin D 24-hydroxylase; FXC9231JVH/Calcitriol

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