Document Detail


Vitamin D may be a link to black-white disparities in adverse birth outcomes.
MedLine Citation:
PMID:  20403218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the United States, significant, intractable disparities exist in rates of major pregnancy outcomes between non-Hispanic black and non-Hispanic white women. A previously unexplored candidate influence on the black-white disparity in adverse birth outcomes is maternal vitamin D status. This review summarizes the evidence relating maternal vitamin D to preeclampsia, spontaneous preterm birth, gestational diabetes, and fetal growth restriction, and addresses gaps in our understanding of the contribution of vitamin D to the intractable black-white disparity in these conditions. The literature reviewed highlights strong biologic plausibility of role for vitamin D in the pathophysiology of these poor pregnancy outcomes. Data also suggest that maternal vitamin D deficiency may increase the risk of preeclampsia and fetal growth restriction. Less research has been done in support of relations with spontaneous preterm birth and gestational diabetes, and fetal and infant survival have rarely been studied. Few trials of vitamin D supplementation have been conducted in pregnant women with adequate power to test effects on birth outcomes. Importantly, black pregnant women have rarely been studied in vitamin D-birth outcomes research. Although vitamin D is a promising candidate influence on black-white disparities in preeclampsia, spontaneous preterm birth, fetal growth restriction, and gestational diabetes, these associations require further study in large samples of black US women. Because vitamin D deficiency is widespread and black-white disparities in pregnancy outcomes and infant survival have been resistant to previous interventions, research to test vitamin D as a causal factor is of major public health significance. Target Audience: Obstetricians & Gynecologist, Family Physicians. Learning Objectives: After completion of this educational activity, the reader will be able to appreciate risk factors for inadequate vitamin D status. Understand the basic aspects of vitamin D metabolism. Become aware of recent literature linking inadequate vitamin D status and adverse pregnancy outcomes such as preeclampsia and preterm birth.
Authors:
Lisa M Bodnar; Hyagriv N Simhan
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Obstetrical & gynecological survey     Volume:  65     ISSN:  1533-9866     ISO Abbreviation:  Obstet Gynecol Surv     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-20     Completed Date:  2010-07-30     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0401007     Medline TA:  Obstet Gynecol Surv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  273-84     Citation Subset:  IM    
Affiliation:
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA 15261, USA. bodnar@edc.pitt.edu
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MeSH Terms
Descriptor/Qualifier:
African Continental Ancestry Group
European Continental Ancestry Group
Female
Humans
Pregnancy
Pregnancy Complications
Pregnancy Outcome / epidemiology*
United States / epidemiology
Vitamin D / physiology*
Vitamin D Deficiency / complications
Grant Support
ID/Acronym/Agency:
K01 MH074092/MH/NIMH NIH HHS; R01 HD041663/HD/NICHD NIH HHS; R01 HD052732/HD/NICHD NIH HHS; R01 HD056999/HD/NICHD NIH HHS; R01 HD056999-01A1/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
1406-16-2/Vitamin D
Comments/Corrections

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