| Vitamin D linked to PFAPA syndrome. | |
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MedLine Citation:
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PMID: 23246421 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE: the etiology and pathogenesis of PFAPA is still unknown, the rapid response to corticosteroids treatment suggested an immune mechanism. The role of vitamin D in the development of immune mediated diseases is widely investigated. In this study we aimed to look for possible association between serum 25-hydroxy vitamin D levels and PFAPA syndrome. METHOD: Twenty-two patients diagnosed with PFAPA followed up at our private clinics between June 2010 and May 2012 were enrolled in the study in addition to 20 patients' age and gender-matched control group. All subjects had complete work-up medical examination and laboratory tests. Laboratory tests included complete blood count, C-reactive protein (CRP), throat culture, and vitamin D levels. RESULTS: mean WBC and CRP values were significantly higher in the PFAPA group (WBC=13.9±2.3×10(3) /mm(2) versus 5.8±3.4×10(3) /mm(2) in the control group (P<0.05) and CRP 37.9±25.7mg/dl versus0.7±1.23mg/dl in the control group (P<0.05)). Vitamin D levels were significantly decreased in PFAPA group as compared with the control (12.27±11.02ng/ml in the PFAPA group versus 20.34±12.64ng/ml in the control group (P<0.05)). Multivariate analysis showed that CRP (odd ratio (OR)=3.0, 95% confidence interval (CI)=2.6-4.2, P=0.01 and serum vitamin D levels <30ng/ml OR=2.6, 95% CI=2.4-3.2, P=0.02 were associated with PFAPA. CONCLUSION: we found a significant correlation between PFAPA and vitamin D deficiency. Vitamin D deficiency can be significant risk factor for PFAPA occurrence. |
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Authors:
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Mahmud Mahamid; Khaled Agbaria; Ammad Mahamid; William Nseir |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-13 |
Journal Detail:
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Title: International journal of pediatric otorhinolaryngology Volume: - ISSN: 1872-8464 ISO Abbreviation: Int. J. Pediatr. Otorhinolaryngol. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8003603 Medline TA: Int J Pediatr Otorhinolaryngol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Internal Medicine, Holy Family Hospital, Nazareth, Israel; Infectious Diseases Unit, Holy Family Hospital, Nazareth, Israel. Electronic address: mahmudmahamid@yahoo.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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