| Vitamin D levels for optimum bone health. | |
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MedLine Citation:
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PMID: 17342288 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Vitamin D deficiency was assessed previously on the basis of rickets and osteomalacia, which represent an extreme end of the spectrum. As a result of this, many clinically-asymptomatic patients go undetected. As vitamin D deficiency results in secondary hyperparathyroidism, we propose to use the normalisation of intact parathyroid hormone (iPTH) as a surrogate marker for assessing the adequacy of vitamin D nutrition. METHODS: A descriptive study was undertaken on 195 premenopausal Pakistani women. 25-hydroxy-cholecalciferol and iPTH levels were measured by standard laboratory techniques. RESULTS: The minimum level of vitamin D required to keep iPTH below 53 pg/dL was found to be 16 ng/ml with a 95 percent confidence interval of 13.8 and 18.2. Existing normal range is 9-36 ng/ml. CONCLUSION: Normalisation of iPTH if taken as a criterion for judging vitamin D deficiency can lead to detection of clinically asymptomatic patients. The simplicity, low cost of correction, and the potential beneficial skeletal and non-skeletal consequences of doing so makes it essential that this criterion be used to redefine the optimal vitamin D levels. This should be internationally standardised and made available to clinicians. |
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Authors:
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F Masud |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Singapore medical journal Volume: 48 ISSN: 0037-5675 ISO Abbreviation: Singapore Med J Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-03-07 Completed Date: 2007-03-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0404516 Medline TA: Singapore Med J Country: Singapore |
Other Details:
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Languages: eng Pagination: 207-12 Citation Subset: IM |
Affiliation:
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Department of Medicine, Services Institute of Medical Sciences, Services Hospital, Jail Road, Lahore 54700, Pakistan. dr.faisalmasud@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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25-Hydroxyvitamin D 2
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blood* Adolescent Adult Age Distribution Female Humans Hyperparathyroidism / blood, prevention & control Middle Aged Parathyroid Hormone / blood* Seasons |
| Chemical | |
Reg. No./Substance:
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0/Parathyroid Hormone; 21343-40-8/25-Hydroxyvitamin D 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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