| Vitamin D levels do not predict cardiovascular events in statin-treated patients with stable coronary disease. | |
| | |
MedLine Citation:
|
PMID: 22980306 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: This post hoc nested case-control analysis of the TNT study was designed to investigate whether baseline vitamin D level is a significant predictor of cardiovascular risk among statin-treated patients and whether changes in vitamin D after treatment with atorvastatin are associated with improved cardiovascular outcomes. METHODS: A total of 10,001 patients with stable coronary heart disease were randomized to atorvastatin 80 or 10 mg for a median of 4.9 years. This analysis included 1,509 patients (497 with a subsequent cardiovascular event and 1,012 without an event) with vitamin D levels determined at baseline and 1 year. Event rates were analyzed by Cox proportional hazard model by baseline vitamin D levels, with vitamin D as a continuous variable, and with change in vitamin D level as the predictor. RESULTS: Vitamin D deficiency (<15 ng/mL) or insufficiency (15- <30 ng/mL) was present in 108 (7.2%) of 1,509 and 625 (41.4%) of 1,509 of patients, whereas 46 (3.0%) of 1,509 had elevated vitamin D. There was no relationship between baseline vitamin D levels or change in vitamin D levels and cardiovascular events or mortality. Modeling of events with vitamin D as a continuous variable similarly showed no relationship of vitamin D to events. These findings held true after adjustment for seasonal variations in vitamin D and other confounders. CONCLUSION: In statin-treated patients with stable coronary heart disease, vitamin D levels did not predict cardiovascular risk. Changes in plasma concentrations of vitamin D after 1 year of treatment made no contribution to the efficacy of atorvastatin therapy. |
| | |
Authors:
|
Vera Bittner; Nanette K Wenger; David D Waters; David A Demicco; Michael Messig; John C Larosa |
Related Documents
:
|
36766 - Informed consent for neuroleptic therapy. 2740326 - Spouses' psychosocial problems, resources, and marital functioning postmyocardial infar... 15557406 - Information and participation preferences of dental patients. 17888616 - Preferences of patients receiving bisphosphonates--how to influence the therapeutic adh... 3740556 - Sensitivity to non-acetylated salicylates in a patient with asthma, nasal polyps, and r... 574226 - Poriomania. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American heart journal Volume: 164 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2012 Sep |
Date Detail:
|
Created Date: 2012-09-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
|
Languages: eng Pagination: 387-93 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2012 Mosby, Inc. All rights reserved. |
Affiliation:
|
University of Alabama at Birmingham, Birmingham, AL. Electronic address: vbittner@uab.edu. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Edifoligide and long-term outcomes after coronary artery bypass grafting: PRoject of Ex-vivo Vein gr...
Next Document: REstoration of COronary flow in patients with no-reflow after primary coronary interVEntion of acute...