Document Detail

Vitamin D level and extent of coronary stenotic lesions in patients with first acute myocardial infarction.
MedLine Citation:
PMID:  23677723     Owner:  NLM     Status:  Publisher    
OBJECTIVES: The study aimed to examine the relationship between vitamin D levels and the extent of coronary stenotic lesions in patients with ST-segment elevation myocardial infarction (STEMI). BACKGROUND: Experimental evidence points to the involvement of multiple factors in coronary plaque formation, including vitamin D. Little is known, however, about the association of vitamin D level with the intensity of atherosclerosis. METHODS: Serum concentrations of 25-hydroxyvitamin D (25(OH)D) were measured in 130 consecutive patients with the first acute STEMI treated with primary percutaneous coronary intervention. STEMI was the first symptom of coronary artery disease (CAD). The study population was divided into patients with single and multi-vessel CAD. The angiographic severity of CAD was also determined based on the Gensini score. RESULTS: The median 25(OH)D concentration was 11.12 ng/mL (25th and 75th percentile: 6.05; 17.12). Insufficient (20-30 ng/mL), deficient (10-20 ng/mL) and severely deficient (30 ng/ml). The 25(OH)D concentrations between patients with single- and multi-vessel CAD did not differ significantly (10.2 vs 11.4 ng/ml, p=0.62). There was no significant correlation between 25(OH)D levels and Gensini Score (r=- 0.0221, p=0,81). CONCLUSIONS: The study demonstrated that vitamin D level is not associated with the severity of coronary lesions in patients with the first STEMI. A high prevalence of vitamin D deficiency in these patients was confirmed.
Beata Małgorzata Goleniewska; Michał Kacprzak; Marzenna Zielinska
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-5-15
Journal Detail:
Title:  Cardiology journal     Volume:  -     ISSN:  1897-5593     ISO Abbreviation:  Cardiol J     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-5-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101392712     Medline TA:  Cardiol J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Cardiac Therapy Clinic, Medical University of Lodz,.
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