| Vitamin D insufficiency together with high serum levels of vitamin A increases the risk for osteoporosis in postmenopausal women. | |
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MedLine Citation:
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PMID: 23417776 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Postmenopausal women who were vitamin D deficient and had high serum levels of retinol had an eight times higher risk of having osteoporosis. A high retinol level together with vitamin D deficiency/insufficiency is an additional risk factor for osteoporosis. PURPOSE: The aim of this study was to evaluate the association between vitamin D deficiency/insufficiency and excess of vitamin A intake as an osteoporosis risk factor in healthy postmenopausal women DESIGN: The design is a cross-sectional study of 232 healthy postmenopausal women. METHODS: Bone mass was evaluated by dual energy X-ray absorptiometry. Serum calcium, albumin phosphorus, creatinine, total high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol, and triglycerides analyzed by standard methods and retinol and 25-hydroxyvitamin D [25(OH)D] measured by an online solid-phase extraction coupled with high-pressure liquid chromatography-ultraviolet detection. RESULTS: Prevalence of vitamin D deficiency [25(OH)D < 20 ng/mL] was 70.1 %; 14.3 % had a 25(OH)D < 10 ng/mL, and 23.6 % had insufficiency [25(OH)D 21-29 ng/mL]. Prevalence of high serum levels of retinol (>80 μg/dL) was 36.4 %. Among subjects with 25(OH)D <20 ng/mL (n = 152), 60.4 % (n = 92) had serum levels of retinol > 80 μg/dL. Bone density measurements revealed that the risk of osteoporosis was ~8 times higher in women with the highest retinol levels, as compared with women with the lowest retinol levels. In women with 25(OH)D < 20 ng/mL, the risk for osteoporosis increased substantially in women who had the highest blood levels of retinol compared to the women with lowest retinol levels. CONCLUSIONS: Higher retinol levels together with vitamin D deficiency could be a significant additional risk factor for osteoporosis, underscoring the need for improved physician and public education regarding optimization of vitamin D status in postmenopausal women and developing policies to avoid high serum levels of vitamin A. |
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Authors:
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J M Mata-Granados; J R Cuenca-Acevedo; M D Luque de Castro; M F Holick; J M Quesada-Gómez |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-2-16 |
Journal Detail:
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Title: Archives of osteoporosis Volume: 8 ISSN: 1862-3514 ISO Abbreviation: Arch Osteoporos Publication Date: 2013 Dec |
Date Detail:
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Created Date: 2013-2-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101318988 Medline TA: Arch Osteoporos Country: - |
Other Details:
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Languages: ENG Pagination: 124 Citation Subset: - |
Affiliation:
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Department of I+D+I, Sanyres Group, Córdoba, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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