| Vitamin D insufficiency and prognosis in chronic lymphocytic leukemia. | |
| | |
MedLine Citation:
|
PMID: 21048153 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Vitamin D insufficiency is common globally and low levels are linked to higher cancer incidence. Although vitamin D insufficiency is related to inferior prognosis in some cancers, no data exist for chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). We evaluated the relationship of 25(OH)D serum levels with time-to-treatment (TTT) and overall survival (OS) in newly diagnosed CLL patients participating in a prospective cohort study (discovery cohort) and a separate cohort of previously untreated patients participating in an observational study (confirmation cohort). Of 390 CLL patients in the discovery cohort, 119 (30.5%) were 25(OH)D insufficient. After a median follow-up of 3 years, TTT (hazard ratio[HR] = 1.66; P = .005) and OS (HR = 2.39; P = .01) were shorter for 25(OH)D-insufficient patients. In the validation cohort, 61 of 153 patients (39.9%) were 25(OH)D insufficient. After a median follow-up of 9.9 years, TTT (HR = 1.59; P = .05) and OS (HR 1.63; P = .06) were again shorter for 25(OH)D-insufficient patients. On pooled multivariable analysis of patients in both cohorts adjusting for age, sex, Rai stage, CD38 status, ZAP-70 status, immunoglobulin heavy chain variable (IGHV) gene mutation status, CD49d status, and cytogenetic abnormalities assessed by interphase fluorescent in situ hybridization testing, 25(OH)D insufficiency remained an independent predictor of TTT (HR = 1.47; P = .008), although the association with OS was not significant (HR = 1.47; P = .07). Vitamin D insufficiency is associated with inferior TTT and OS in CLL patients. Whether normalizing vitamin D levels in deficient CLL patients would improve outcome merits clinical testing. |
| | |
Authors:
|
Tait D Shanafelt; Matthew T Drake; Matthew J Maurer; Cristine Allmer; Kari G Rabe; Susan L Slager; George J Weiner; Timothy G Call; Brian K Link; Clive S Zent; Neil E Kay; Curtis A Hanson; Thomas E Witzig; James R Cerhan |
Related Documents
:
|
6336043 - Effect of treatment on the cellular composition of cutaneous lesions in leprosy patients. 2232803 - Preoperative cell-mediated immune function and the prognosis of patients with gastric c... 18181053 - Sudden cardiac death risk factors in patients with heart failure treated with carvedilol. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-11-03 |
Journal Detail:
|
Title: Blood Volume: 117 ISSN: 1528-0020 ISO Abbreviation: Blood Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-02-04 Completed Date: 2011-04-14 Revised Date: 2012-02-03 |
Medline Journal Info:
|
Nlm Unique ID: 7603509 Medline TA: Blood Country: United States |
Other Details:
|
Languages: eng Pagination: 1492-8 Citation Subset: AIM; IM |
Affiliation:
|
Division of Hematology, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Antigens, CD38 / metabolism Chromatography, Liquid Cohort Studies Female Humans In Situ Hybridization, Fluorescence Leukemia, Lymphocytic, Chronic, B-Cell / blood*, drug therapy, mortality Male Middle Aged Prognosis Prospective Studies Survival Rate Tandem Mass Spectrometry Tumor Markers, Biological / blood* Vitamin D / analogs & derivatives*, blood Vitamin D Deficiency / blood*, drug therapy, mortality ZAP-70 Protein-Tyrosine Kinase / genetics |
| Grant Support | |
ID/Acronym/Agency:
|
CA 113408/CA/NCI NIH HHS; P50 CA97274/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Tumor Markers, Biological; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D; EC 2.7.1.112/ZAP70 protein, human; EC 2.7.10.2/ZAP-70 Protein-Tyrosine Kinase; EC 3.2.2.5/Antigens, CD38 |
| Comments/Corrections | |
Comment In:
|
Blood. 2011 Feb 3;117(5):1439-40
[PMID:
21292782
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Flagellin as an adjuvant: cellular mechanisms and potential.
Next Document: Recent thymic emigrants are biased against the T-helper type 1 and toward the T-helper type 2 effect...