Document Detail

Vitamin D and innate immunity.
MedLine Citation:
PMID:  18465658     Owner:  NLM     Status:  MEDLINE    
It is becoming increasingly clear that vitamin D can exert effects on human physiology beyond its long-standing association with skeletal homeostasis. In particular, the ability of active 1,25-dihydroxyvitamin D (1,25(OH)2D) to function as a potent modulator of human immune responses has attracted much attention. Over the last ten years, most studies on the relationship between vitamin D and immunity have focused on the effects of 1,25(OH)2D on lymphocytes and adaptive immunity; however, studies have shown that local macrophage synthesis of 1,25(OH)2D in response to TLR signaling is also a key feature of innate immunity. This new facet of 'non-classical' roles of vitamin D action is discussed in this review.
Martin Hewison
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in investigational drugs (London, England : 2000)     Volume:  9     ISSN:  1472-4472     ISO Abbreviation:  Curr Opin Investig Drugs     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-09     Completed Date:  2008-09-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100965718     Medline TA:  Curr Opin Investig Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  485-90     Citation Subset:  IM    
University of California, Los Angeles, David Geffen School of Medicine, Department of Orthopedic Surgery, 615 Charles E Young Drive South, Los Angeles, CA 90095, USA.
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MeSH Terms
Anti-Bacterial Agents / pharmacology
Immunity, Innate*
Macrophages / metabolism
Toll-Like Receptors / physiology
Vitamin D / analogs & derivatives,  biosynthesis,  pharmacology,  physiology*
Vitamins / pharmacology
Grant Support
R01AR050626/AR/NIAMS NIH HHS; //Biotechnology and Biological Sciences Research Council
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Toll-Like Receptors; 0/Vitamins; 1406-16-2/Vitamin D; 66772-14-3/1,25-dihydroxyvitamin D

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