| Vitamin D and innate immunity. | |
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MedLine Citation:
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PMID: 18465658 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is becoming increasingly clear that vitamin D can exert effects on human physiology beyond its long-standing association with skeletal homeostasis. In particular, the ability of active 1,25-dihydroxyvitamin D (1,25(OH)2D) to function as a potent modulator of human immune responses has attracted much attention. Over the last ten years, most studies on the relationship between vitamin D and immunity have focused on the effects of 1,25(OH)2D on lymphocytes and adaptive immunity; however, studies have shown that local macrophage synthesis of 1,25(OH)2D in response to TLR signaling is also a key feature of innate immunity. This new facet of 'non-classical' roles of vitamin D action is discussed in this review. |
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Authors:
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Martin Hewison |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current opinion in investigational drugs (London, England : 2000) Volume: 9 ISSN: 1472-4472 ISO Abbreviation: Curr Opin Investig Drugs Publication Date: 2008 May |
Date Detail:
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Created Date: 2008-05-09 Completed Date: 2008-09-05 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 100965718 Medline TA: Curr Opin Investig Drugs Country: England |
Other Details:
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Languages: eng Pagination: 485-90 Citation Subset: IM |
Affiliation:
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University of California, Los Angeles, David Geffen School of Medicine, Department of Orthopedic Surgery, 615 Charles E Young Drive South, Los Angeles, CA 90095, USA. mhewison@mednet.ucla.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Bacterial Agents / pharmacology Humans Immunity, Innate* Macrophages / metabolism Toll-Like Receptors / physiology Vitamin D / analogs & derivatives, biosynthesis, pharmacology, physiology* Vitamins / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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R01AR050626/AR/NIAMS NIH HHS; //Biotechnology and Biological Sciences Research Council |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Toll-Like Receptors; 0/Vitamins; 1406-16-2/Vitamin D; 66772-14-3/1,25-dihydroxyvitamin D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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