Document Detail

Vitamin D inadequacy in pregnancy: biology, outcomes, and interventions.
MedLine Citation:
PMID:  20646224     Owner:  NLM     Status:  MEDLINE    
A high prevalence of maternal vitamin D inadequacy during pregnancy and at delivery has been demonstrated in various ethnic populations living at different latitudes. Because placental transfer of 25(OH)D is the major source of vitamin D to the developing human fetus, there is growing concern about adverse health impacts that hypovitaminosis D during pregnancy may have on the mother as well as the offspring in utero, in infancy, and later in life. While there is lack of consensus regarding the optimal circulating 25(OH)D concentration in pregnancy, it is evident that prior levels used to establish intake recommendations and vitamin D content of prenatal vitamin supplements were too conservative. This review summarizes vitamin D metabolism in the perinatal period, examines evidence regarding outcomes of insufficiency in the mother and offspring, discusses risk factors and prevalence of insufficiency, and considers strategies for public health intervention.
Daphna K Dror; Lindsay H Allen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nutrition reviews     Volume:  68     ISSN:  1753-4887     ISO Abbreviation:  Nutr. Rev.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-21     Completed Date:  2010-09-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376405     Medline TA:  Nutr Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  465-77     Citation Subset:  IM    
USDA ARS Western Human Nutrition Research Center, Davis, California 95616, USA.
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MeSH Terms
Adaptation, Physiological
Bone Density Conservation Agents / metabolism,  therapeutic use*
Dietary Supplements
Maternal Nutritional Physiological Phenomena / physiology*
Nutrition Policy
Nutritional Requirements
Pregnancy Complications / epidemiology,  prevention & control
Pregnancy Outcome*
Prenatal Nutritional Physiological Phenomena / physiology*
Public Health
Treatment Outcome
Vitamin D / metabolism,  therapeutic use*
Vitamin D Deficiency / epidemiology*,  prevention & control
Reg. No./Substance:
0/Bone Density Conservation Agents; 1406-16-2/Vitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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