| Vitamin D in the maternal-fetal-neonatal interface: Clinical implications and requirements for supplementation. | |
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MedLine Citation:
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PMID: 23131182 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Identification of the current evidence regarding the pathophysiological and clinical facets of vitamin D in the maternal-fetal-neonatal interface is of value because of the significance of the vitamin D endocrine system in human health and high prevalence of vitamin D deficiency in mothers and their infants. Although many questions have still not been answered by the existing literature, we found evidence that: (i) during pregnancy vitamin D participates in fetal skeletal mineralization and growth, (ii) neonatal vitamin D level are dependent on the maternal vitamin D status at delivery, (iii) a vitamin D sufficient status at birth may decrease the risk for the development of asthma and type 1 diabetes mellitus in later life, (iv) recommendations for maintaining serum 25-hydroxyvitamin D [25(OH)D] levels >32 ng/mL to avoid secondary hyperparathyroidism in adults has not been applied to mothers and their infants, (v) American Academy of Pediatrics recommended supplementation of 400 IU of vitamin D per day is sufficient only for infants who are born with normal vitamin D levels, (vii) supplementation of lactating mothers with high doses of vitamin D (4,000 IU /d) allows the achievement of optimal 25(OH)D concentrations (>32 ng/mL) in the maternal and infant serum without any risk of hypervitaminosis D in the mother. We believe that inconsistency in the recognition of sufficient levels of vitamin D in mothers and their infants affects the identification of adequate doses for vitamin D supplementation during pregnancy, lactation, and infancy. |
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Authors:
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Ian Marshall; Rajeev Mehta; Anna Petrova |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-11-6 |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: - ISSN: 1476-4954 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2012 Nov |
Date Detail:
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Created Date: 2012-11-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pediatrics, UMDNJ/Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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