Document Detail

Vitamin D in children and adolescents.
MedLine Citation:
PMID:  22536773     Owner:  NLM     Status:  MEDLINE    
Vitamin D is essential for bone growth and development in children and adolescents. Vitamin D deficiency leads to rickets, characterized by defective bone formation, in infants and children. Vitamin D prophylaxis during the first years of life has empirically shown to be effective in combating rickets in infants in some countries. Vitamin D insufficiency can have negative effects on bone health in older children and in adolescents. Vitamin D supplementation has been shown to have an effect on bone mineral density at least in vitamin D deprived older children and adolescents but not in those with a normal vitamin D status. A good vitamin D status during pregnancy seems to be important for bone health in the off-spring later in life, but randomized controlled studies are needed to establish an effect of vitamin D during pregnancy on bone and other health outcomes in the offspring. Vitamin D supplementation during childhood may offer protection against diabetes type 1, but randomized controlled trials are needed to ascertain causality.
Christel Lamberg-Allardt
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation. Supplementum     Volume:  243     ISSN:  0085-591X     ISO Abbreviation:  Scand. J. Clin. Lab. Invest. Suppl.     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-27     Completed Date:  2012-08-20     Revised Date:  2014-08-04    
Medline Journal Info:
Nlm Unique ID:  2984789R     Medline TA:  Scand J Clin Lab Invest Suppl     Country:  England    
Other Details:
Languages:  eng     Pagination:  124-8     Citation Subset:  IM    
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MeSH Terms
Bone Density
Diabetes Mellitus, Type 1 / prevention & control
Dietary Supplements
Rickets / etiology
Vitamin D / administration & dosage,  analogs & derivatives,  blood,  physiology*
Reg. No./Substance:
1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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