| Vitamin D in atherosclerosis, vascular disease, and endothelial function. | |
| | |
MedLine Citation:
|
PMID: 20795937 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Vitamin D deficiency has been linked to an increased risk of hypertension, diabetes, congestive heart failure, peripheral arterial disease, myocardial infarction, stroke, and related mortality, even after adjustment for traditional cardiovascular risk factors. Accumulating evidence from experimental, clinical, and epidemiological studies suggests that vitamin D may also be associated with several indices of vascular function, including the development and progression of atherosclerotic cardiovascular disease. These findings may provide at least a partial explanation for several recent epidemiologic studies implicating low vitamin D status in the pathogenesis of cardiovascular disease. However, many questions still remain. Only a handful of studies are currently available, and the results of these studies have generally been mixed. Additionally, it is unknown whether findings differ across varied subpopulations, including minority subgroups in the United States, younger adults, and those residing in areas with varying amounts of regular sunlight. Furthermore, the exact mechanism by which vitamin D may influence the atherosclerotic disease process has not yet been completely elucidated. In addition, if vitamin D is important in the etiology of atherosclerosis, it is unclear at what stage(s) in the atherosclerotic disease process vitamin D may exert its effects. Large-scale, well-conducted, placebo controlled clinical trials testing the efficacy of vitamin D supplementation in delaying, slowing, or reverting the atherosclerotic disease process have not yet been conducted. Until the results of these studies are available, we believe it is premature to recommend vitamin D as a therapeutic option in atherosclerosis. |
| | |
Authors:
|
LaPrincess C Brewer; Erin D Michos; Jared P Reis |
Related Documents
:
|
10448607 - Homocysteine as a novel risk factor for atherosclerosis. 19269107 - Crohn's disease: the hot hypothesis. 8986467 - The value of the dehydroepiandrosterone-annexed vitamin c infusion treatment in the cli... 9659257 - Acp broadsheet no 152: march 1998. clinical implications of plasma homocysteine measure... 20043617 - Hemoptysis in a patient with tracheopathia osteochondroplasia. 2096847 - The effect of selenium-fortified table salt in the prevention of keshan disease on a po... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Current drug targets Volume: 12 ISSN: 1873-5592 ISO Abbreviation: Curr Drug Targets Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2010-12-06 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 100960531 Medline TA: Curr Drug Targets Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 54-60 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Johns Hopkins Bayview Medical Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vitamin D insufficiency and diabetes risks.
Next Document: Vitamin D in chronic kidney disease: new potential for intervention.