| Vitamin D: immunomodulation of asthma, allergic rhinitis, and chronic rhinosinusitis. | |
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MedLine Citation:
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PMID: 21499100 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: To discuss the role of vitamin D in asthma, allergic rhinitis, and chronic rhinosinusitis (CRS). RECENT FINDINGS: Over the last several years, the role of vitamin D in immunomodulation has been studied and shown to have a significant impact on immune function. A causal relationship exists between vitamin D function and innate and adaptive immunity to infections. The mechanisms underlying vitamin D immune actions could be attributed to a paracrine feedback loop that reduces inflammation as well as influencing the differentiation fate of activated CD4 T cells, or the enhancement of suppressor T-cell function; indeed, a combination of these factors may underlie the actions of vitamin D. SUMMARY: Recent findings on the function of vitamin D may explain aspects of the pathophysiology of allergic rhinitis and CRS and may help direct future interventions and treatment of these diseases. |
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Authors:
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Nadeem A Akbar; Mark A Zacharek |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-15 |
Journal Detail:
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Title: Current opinion in otolaryngology & head and neck surgery Volume: - ISSN: 1531-6998 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-4-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9417024 Medline TA: Curr Opin Otolaryngol Head Neck Surg Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Otolaryngology/Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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