Document Detail

Vitamin D and hypertension: an update and review.
MedLine Citation:
PMID:  22820371     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Vitamin D deficiency and hypertension are highly prevalent. This review will discuss the association between vitamin D deficiency and blood pressure.
RECENT FINDINGS: During the past several years multiple prospective cohorts and randomized studies have been published. Recent studies have focused mostly on 25-hydroxy vitamin D, but a small number of trials used active vitamin D analog compounds.
SUMMARY: Data from cross-sectional studies report that low 25-hydroxy vitamin D is associated with higher systolic blood pressure and higher incidence of hypertension. Large observational studies show a weaker, yet similar association, but they have not largely accounted for the change in vitamin D levels over time. Randomized control trials conflict with observational data probably due to differences in populations studied, doses of vitamin D used, and unmeasured confounders. Further research is needed before clinical practice recommends vitamin D prescription as treatment for hypertension in the general population.
Hector Tamez; Ravi I Thadhani
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Review    
Journal Detail:
Title:  Current opinion in nephrology and hypertension     Volume:  21     ISSN:  1473-6543     ISO Abbreviation:  Curr. Opin. Nephrol. Hypertens.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-09     Completed Date:  2013-01-03     Revised Date:  2013-05-02    
Medline Journal Info:
Nlm Unique ID:  9303753     Medline TA:  Curr Opin Nephrol Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  492-9     Citation Subset:  IM    
Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
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MeSH Terms
Cardiovascular Diseases / complications,  drug therapy,  etiology
Clinical Trials as Topic
Hypertension / complications*,  drug therapy*
Risk Factors
Vitamin D / blood,  therapeutic use*
Vitamin D Deficiency / complications*,  drug therapy*
Reg. No./Substance:
1406-16-2/Vitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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