Document Detail

Vitamin D endocrine system and psoriasis vulgaris--review of the literature.
MedLine Citation:
PMID:  19818218     Owner:  NLM     Status:  MEDLINE    
Vitamin D exerts its physiological functions on calcium and bone metabolism in humans through the active metabolite 1,25-dihydroxyvitamin D3(1,25(OH)2D3). The other spectrum of vitamin D activities includes important effects on cellular proliferation, differentiation and the immune system. These effects are mediated through the intracellularly located vitamin D receptor (VDR). VDR is a member of the steroid, estrogen and retinoid receptor gene family of proteins that mediate transcriptional activities of the respective ligands. The VDR complex binds in the nucleus to the vitamin D responsive element on the gene. Several polymorphisms of the vitamin D receptor (VDR) gene have been described including FokI in exon 2, BsmI and ApaI in intron 8 and TaqI in exon 9. Alterations in vitamin D-1,25 (OH)2D3 levels and polymorphisms of VDR gene have been shown to be associated with several malignant or autoimmune diseases such as sclerosis multiplex, breast cancer, diabetes mellitus, malignant melanoma, and psoriasis vulgaris. The effects of VDR gene polymorphisms including immunomodulation, stimulation of cellular differentiation and inhibition of proliferation make it a possible candidate for therapy of psoriasis as well as for the psoriasis gene modification. The objective of this article is to present the state-of-the-art in the VDR gene polymorphism research in psoriasis vulgaris.
Ivana Rucević; Vladimira Barisić-Drusko; Ljubica Glavas-Obrovac; Mario Stefanić
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Acta dermatovenerologica Croatica : ADC     Volume:  17     ISSN:  1330-027X     ISO Abbreviation:  Acta Dermatovenerol Croat     Publication Date:  2009  
Date Detail:
Created Date:  2009-10-12     Completed Date:  2010-08-26     Revised Date:  2011-09-13    
Medline Journal Info:
Nlm Unique ID:  9433781     Medline TA:  Acta Dermatovenerol Croat     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  187-92     Citation Subset:  IM    
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MeSH Terms
Polymorphism, Genetic*
Psoriasis / genetics*,  metabolism
Receptors, Calcitriol / genetics*,  metabolism
Vitamin D / genetics*,  metabolism,  pharmacology
Reg. No./Substance:
0/Receptors, Calcitriol; 1406-16-2/Vitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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