| Vitamin D endocrine system and psoriasis vulgaris--review of the literature. | |
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MedLine Citation:
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PMID: 19818218 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vitamin D exerts its physiological functions on calcium and bone metabolism in humans through the active metabolite 1,25-dihydroxyvitamin D3(1,25(OH)2D3). The other spectrum of vitamin D activities includes important effects on cellular proliferation, differentiation and the immune system. These effects are mediated through the intracellularly located vitamin D receptor (VDR). VDR is a member of the steroid, estrogen and retinoid receptor gene family of proteins that mediate transcriptional activities of the respective ligands. The VDR complex binds in the nucleus to the vitamin D responsive element on the gene. Several polymorphisms of the vitamin D receptor (VDR) gene have been described including FokI in exon 2, BsmI and ApaI in intron 8 and TaqI in exon 9. Alterations in vitamin D-1,25 (OH)2D3 levels and polymorphisms of VDR gene have been shown to be associated with several malignant or autoimmune diseases such as sclerosis multiplex, breast cancer, diabetes mellitus, malignant melanoma, and psoriasis vulgaris. The effects of VDR gene polymorphisms including immunomodulation, stimulation of cellular differentiation and inhibition of proliferation make it a possible candidate for therapy of psoriasis as well as for the psoriasis gene modification. The objective of this article is to present the state-of-the-art in the VDR gene polymorphism research in psoriasis vulgaris. |
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Authors:
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Ivana Rucević; Vladimira Barisić-Drusko; Ljubica Glavas-Obrovac; Mario Stefanić |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Acta dermatovenerologica Croatica : ADC Volume: 17 ISSN: 1330-027X ISO Abbreviation: Acta Dermatovenerol Croat Publication Date: 2009 |
Date Detail:
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Created Date: 2009-10-12 Completed Date: 2010-08-26 Revised Date: 2011-09-13 |
Medline Journal Info:
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Nlm Unique ID: 9433781 Medline TA: Acta Dermatovenerol Croat Country: Croatia |
Other Details:
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Languages: eng Pagination: 187-92 Citation Subset: IM |
Affiliation:
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ivana.rucevic2@os.t-com.hr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Humans Immunomodulation Polymorphism, Genetic* Psoriasis / genetics*, metabolism Receptors, Calcitriol / genetics*, metabolism Vitamin D / genetics*, metabolism, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Calcitriol; 1406-16-2/Vitamin D |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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