Document Detail


Vitamin D effects on pregnancy and the placenta.
MedLine Citation:
PMID:  20863562     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vitamin D is a pleiotropic secosteroid hormone important for health and disease prevention. The actions of vitamin D are mediated by the vitamin D receptor that binds the active form of vitamin D [1,25(OH)(2)D] to induce both transcriptional and non-genomic responses. Vitamin D has well known classical functions in calcium uptake and bone metabolism, but more recent work highlights the importance of the nonclassical actions of vitamin D in a variety of cell types. These actions include modulation of the innate and adaptive immune systems and regulation of cell proliferation. Adequate vitamin D intake is essential for maternal and fetal health during pregnancy, and epidemiological data indicate that many pregnant women have sub-optimal vitamin D levels. Notably, vitamin D deficiency correlates with preeclampsia, gestational diabetes mellitus, and bacterial vaginosis, and an increased risk for C-section delivery. Recent work emphasizes the importance of nonclassical roles of vitamin D in pregnancy and the placenta. The placenta produces and responds to vitamin D where vitamin D functions as a modulator of implantation, cytokine production and the immune response to infection. We describe vitamin D metabolism and the cellular responses to vitamin D, and then summarize the role of vitamin D in placental trophoblast, pregnancy and the fetus.
Authors:
J S Shin; M Y Choi; M S Longtine; D M Nelson
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2010-09-22
Journal Detail:
Title:  Placenta     Volume:  31     ISSN:  1532-3102     ISO Abbreviation:  Placenta     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-11-29     Completed Date:  2011-03-29     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  8006349     Medline TA:  Placenta     Country:  England    
Other Details:
Languages:  eng     Pagination:  1027-34     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Chorionic Villi / metabolism*
Female
Humans
Pregnancy / metabolism*
Trophoblasts / metabolism*
Vitamin D / metabolism*
Grant Support
ID/Acronym/Agency:
R01 HD029190/HD/NICHD NIH HHS; R01 HD029190-13/HD/NICHD NIH HHS; R01-HD29190/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
1406-16-2/Vitamin D
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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