| Vitamin D does not improve the metabolic health of patients with Chronic Kidney Disease stage 3 - 4: a randomised controlled trial. | |
| | |
MedLine Citation:
|
PMID: 23043683 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
AIMS: To assess the impact of vitamin D supplementation (cholecalciferol) on the insulin sensitivity and metabolic health of patients with chronic kidney disease. METHODS: 28 adult patients with CKD stages 3-4 were recruited from the out-patient department of the Princess Alexandra Hospital (Brisbane, Australia) to a double-blind randomised trial of Cholecalciferol (vitamin D3) 2,000IU/day or placebo for 6 months. Metabolic parameters at baseline were compared to 20 non-CKD adults. The primary outcome was an improvement in insulin resistance (Glucose Disposal Rate, GDR) at six months (quantified by hyperinsulinaemic euglycaemic clamp). Carbohydrate and lipid oxidation rates were assessed by indirect calorimetry. RESULTS: At baseline, patients were significantly insulin resistant compared to lean younger non-CKD individuals (n=9; GDR 3.42 vs. 5.76mg/kg/min, p=0.001), but comparable to their age, gender and weight matched non-CKD counterparts (n=11; 3.42 vs. 3.98mg/kg/min, p=0.4). 25-hydroxyvitamin D did not change in the placebo group, but rose from 95±37 to 146±25nmol/L with treatment (p=0.0001). Post treatment, there was no difference in GDR between groups (GDR 3.38 vs. 3.52mg/kg/min, ANCOVA p=0.4). There was a relative increase in hyperinsulinaemic oxidative disposal of glucose with treatment (within group p=0.03). CONCLUSIONS: Supplementation with cholecalciferol in CKD 3-4 results in appreciable increases in 25-hydroxyvitamin D concentrations, but does not increase insulin sensitivity. The insulin resistance observed was similar amongst age, sex, and BMI matched individuals with and without CKD. Whether renal dysfunction per se has any influence on the insulin sensitivity of an individual should be the subject of future work. |
| | |
Authors:
|
William G Petchey; Ingrid J Hickman; Johannes B Prins; Carmel M Hawley; David W Johnson; Nicole M Isbel |
Related Documents
:
|
23443033 - The effect of vitamin d on insulin resistance in patients with type 2 diabetes. 14705793 - Carbohydrate expression and modification during keratinocyte differentiation in normal ... 12458403 - Dysregulation of coronary microvascular reactivity in asymptomatic patients with type 2... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-10-9 |
Journal Detail:
|
Title: Nephrology (Carlton, Vic.) Volume: - ISSN: 1440-1797 ISO Abbreviation: Nephrology (Carlton) Publication Date: 2012 Oct |
Date Detail:
|
Created Date: 2012-10-9 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9615568 Medline TA: Nephrology (Carlton) Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 The Authors. Nephrology © 2012 Asian Pacific Society of Nephrology. |
Affiliation:
|
Department of Nephrology, Princess Alexandra Hospital, Brisbane, Australia; Centre for Clinical Research Excellence - Cardiovascular Disease and Metabolic Disorders, University of Queensland, Brisbane, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Predischarge Screening for Severe Neonatal Hyperbilirubinemia Identifies Infants Who Need Photothera...
Next Document: Differential expression of G-protein-coupled estrogen receptor-30 in human myometrial and uterine le...