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Vitamin D and disease activity in multiple sclerosis before and during interferon-β treatment.
MedLine Citation:
PMID:  22700809     Owner:  NLM     Status:  Publisher    
OBJECTIVE:Studies based on deseasonalized vitamin D levels suggest that vitamin D may influence the disease activity in multiple sclerosis (MS), and high doses are suggested as add-on treatment to interferon-β (IFN-β). Seasonal fluctuation of vitamin D varies between individuals, thus the relationship to disease activity should preferentially be studied by repeated and simultaneous vitamin D and MRI measurements from each patient. METHODS:This was a cohort study comprising 88 patients with relapsing-remitting MS who were followed for 6 months with 7 MRI and 4 25-hydroxyvitamin D measurements before initiation of IFN-β, and for 18 months with 5 MRI and 5 25-hydroxyvitamin D measurements during IFN-β treatment. RESULTS:Prior to IFN-β treatment, each 10 nmol/L increase in 25-hydroxyvitamin D was associated with 12.7% (p = 0.037) reduced odds for new T1 gadolinium-enhancing lesions, 11.7% (p = 0.044) for new T2 lesions, and 14.1% (p = 0.024) for combined unique activity. Patients with the most pronounced fluctuation in 25-hydroxyvitamin D displayed larger proportion of MRI scans with new T1 gadolinium-enhancing lesions (51% vs 23%, p = 0.004), combined unique activity (60% vs 32%, p = 0.003), and a trend for new T2 lesions (49% vs 28%, p = 0.052) at the lowest compared to the highest 25-hydroxyvitamin D level. No association between 25-hydroxyvitamin D and disease activity was detected after initiation of IFN-β. HLA-DRB1*15 status did not affect the results. CONCLUSION:In untreated patients with MS, increasing levels of 25-hydroxyvitamin D are inversely associated with radiologic disease activity irrespective of their HLA-DRB1*15 status.
Kristin I Løken-Amsrud; Trygve Holmøy; Søren J Bakke; Antonie Giaever Beiske; Kristian S Bjerve; Bård T Bjørnarå; Harald Hovdal; Finn Lilleås; Rune Midgard; Tom Pedersen; Jurate Saltyte Benth; Leiv Sandvik; Oivind Torkildsen; Stig Wergeland; Kjell-Morten Myhr
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-13
Journal Detail:
Title:  Neurology     Volume:  -     ISSN:  1526-632X     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the Department of Neurology (K.I.L.-A.), Innlandet Hospital Trust, Lillehammer; Department of Neurology (T.H., A.G.B.), Akershus University Hospital, Lørenskog; Institute of Immunology (T.H.), Department of Neuroradiology (S.J.B.), and Department of Biostatistics (L.S.), Oslo University Hospital, Oslo; Institute of Clinical Medicine (K.I.L.-A., T.H.), University of Oslo, Oslo; Departments of Medical Biochemistry (K.S.B.) and Neurology (H.H.), St. Olavs Hospital, Trondheim University Hospital, Trondheim; Helsehuset Kongsberg (B.T.B.), Kongsberg; Curato Oslo (F.L.), Oslo; Department of Neurology (R.M.), Molde Hospital, Molde; Unilabs Drammen (T.P.), Drammen; Helse Sør-Øst Health Services Research Centre (J.Š.), Akershus University Hospital, Lørenskog; Norwegian Multiple Sclerosis Competence Centre (Ø.T., S.W., K.-M.M.), Department of Neurology, Haukeland University Hospital, Bergen; Department of Clinical Medicine (K.-M.M.), University of Bergen, Bergen; and KG Jebsen MS-Research Centre (K.-M.M.), Bergen, Norway.
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