Document Detail

Vitamin D deficiency and whole-body and femur bone mass relative to weight in healthy newborns.
MedLine Citation:
PMID:  15767609     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Vitamin D is required for normal bone growth and mineralization. We sought to determine whether vitamin D deficiency at birth is associated with bone mineral content (BMC) of Canadian infants.
METHODS: We measured plasma 25-hydroxyvitamin D [25(OH)D] as an indicator of vitamin D status in 50 healthy mothers and their newborn term infants. In the infants, anthropometry and lumbar, femur and whole-body BMC were measured within 15 days of delivery. Mothers completed a 24-hour recall and 3-day food and supplement record. We categorized the vitamin D status of mothers and infants as deficient or adequate and then compared infant bone mass in these groups using nonpaired t tests. Maternal and infant variables known to be related to bone mass were tested for their relation to BMC using backward stepwise regression analysis.
RESULTS: Twenty-three (46%) of the mothers and 18 (36%) of the infants had a plasma 25(OH)D concentration consistent with deficiency. Infants who were vitamin D deficient were larger at birth and follow-up. Absolute lumbar spine, femur and whole-body BMC were not different between infants with adequate vitamin D and those who were deficient, despite larger body size in the latter group. In the regression analysis, higher whole-body BMC was associated with greater gestational age and weight at birth as well as higher infant plasma 25(OH)D.
CONCLUSION: A high rate of vitamin D deficiency was observed among women and their newborn infants. Among infants, vitamin D deficiency was associated with greater weight and length but lower bone mass relative to body weight. Whether a return to normal vitamin D status, achieved through supplements or fortified infant formula, can reset the trajectory for acquisition of BMC requires investigation.
Hope Weiler; Shirley Fitzpatrick-Wong; Rebecca Veitch; Heather Kovacs; Jeannine Schellenberg; Ursula McCloy; Chui Kin Yuen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne     Volume:  172     ISSN:  1488-2329     ISO Abbreviation:  CMAJ     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-03-15     Completed Date:  2005-07-14     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  9711805     Medline TA:  CMAJ     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  757-61     Citation Subset:  AIM; IM    
Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Man.
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MeSH Terms
Body Height
Body Weight
Bone Density*
Dietary Supplements
Femur / physiology
Gestational Age
Infant, Newborn
Linear Models
Vitamin D / analogs & derivatives*,  blood
Vitamin D Deficiency / physiopathology*
Reg. No./Substance:
1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D
Comment In:
CMAJ. 2005 Mar 15;172(6):769-70   [PMID:  15767611 ]
CMAJ. 2005 Sep 27;173(7):733; author reply 733-4   [PMID:  16186568 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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