| Vitamin D deficiency and whole-body and femur bone mass relative to weight in healthy newborns. | |
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MedLine Citation:
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PMID: 15767609 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Vitamin D is required for normal bone growth and mineralization. We sought to determine whether vitamin D deficiency at birth is associated with bone mineral content (BMC) of Canadian infants. METHODS: We measured plasma 25-hydroxyvitamin D [25(OH)D] as an indicator of vitamin D status in 50 healthy mothers and their newborn term infants. In the infants, anthropometry and lumbar, femur and whole-body BMC were measured within 15 days of delivery. Mothers completed a 24-hour recall and 3-day food and supplement record. We categorized the vitamin D status of mothers and infants as deficient or adequate and then compared infant bone mass in these groups using nonpaired t tests. Maternal and infant variables known to be related to bone mass were tested for their relation to BMC using backward stepwise regression analysis. RESULTS: Twenty-three (46%) of the mothers and 18 (36%) of the infants had a plasma 25(OH)D concentration consistent with deficiency. Infants who were vitamin D deficient were larger at birth and follow-up. Absolute lumbar spine, femur and whole-body BMC were not different between infants with adequate vitamin D and those who were deficient, despite larger body size in the latter group. In the regression analysis, higher whole-body BMC was associated with greater gestational age and weight at birth as well as higher infant plasma 25(OH)D. CONCLUSION: A high rate of vitamin D deficiency was observed among women and their newborn infants. Among infants, vitamin D deficiency was associated with greater weight and length but lower bone mass relative to body weight. Whether a return to normal vitamin D status, achieved through supplements or fortified infant formula, can reset the trajectory for acquisition of BMC requires investigation. |
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Authors:
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Hope Weiler; Shirley Fitzpatrick-Wong; Rebecca Veitch; Heather Kovacs; Jeannine Schellenberg; Ursula McCloy; Chui Kin Yuen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne Volume: 172 ISSN: 1488-2329 ISO Abbreviation: CMAJ Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-03-15 Completed Date: 2005-07-14 Revised Date: 2013-04-18 |
Medline Journal Info:
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Nlm Unique ID: 9711805 Medline TA: CMAJ Country: Canada |
Other Details:
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Languages: eng Pagination: 757-61 Citation Subset: AIM; IM |
Affiliation:
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Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Man. hweiler@cc.umanitoba.ca |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Body Height Body Weight Bone Density* Dietary Supplements Female Femur / physiology Gestational Age Humans Infant, Newborn Linear Models Male Vitamin D / analogs & derivatives*, blood Vitamin D Deficiency / physiopathology* |
| Chemical | |
Reg. No./Substance:
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1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D |
| Comments/Corrections | |
Comment In:
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CMAJ. 2005 Mar 15;172(6):769-70
[PMID:
15767611
]
CMAJ. 2005 Sep 27;173(7):733; author reply 733-4 [PMID: 16186568 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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