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Vitamin D deficiency is unrelated to type of atrial fibrillation and its complications.
MedLine Citation:
PMID:  22951200     Owner:  NLM     Status:  In-Data-Review    
INTRODUCTION: Vitamin D plays an important role in a broad range of organ functions, including the cardiovascular system. Only one study has tested the association between vitamin D deficiency and arrhythmia and it found no association. The aim of the present study was to evaluate the association between vitamin D deficiency and the type of atrial fibrillation (AF) and complications to AF.
MATERIAL AND METHODS: In total, 258 patients were consecutively included from March 2009 to February 2011. All in- and out-patients in the Department of Cardiology at Hvidovre Hospital were invited to participate, provided they had electrocardiographically documented AF. Patients with dementia or terminal illness were excluded. 25 hydroxyvitamin D (25 OHD) was measured with a chemiluminescence assay (Liaison from DiaSorin, Stillwater, Minnesota, USA).
RESULTS: No association between vitamin D level and type of AF was found. Furthermore, no association between vitamin D deficiency and ischaemic heart disease, stroke or acute myocardial infarction was found. Vitamin D deficiency was significantly associated with low age (p = 0.02) and gender with a higher proportion of females having the optimal level of 25 OHD (p = 0.0005).
CONCLUSION: Other studies have found a beneficial effect of vitamin D on cardiovascular diseases, but we found no association between vitamin D deficiency and the type of AF or complications to AF. Further investigation is necessary to determine whether vitamin D supplementation improves cardiovascular outcomes in patients with AF.
FUNDING: The study has received financial support from several private and one public fund.
TRIAL REGISTRATION: The study was approved by the National Ethics Committee (Project-ID: H-C-2009-014).
Faiza Qayyum; Nadia Lander Landex; Bue Ross Agner; Michella Rasmussen; Christian Jøns; Ulrik Dixen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Danish medical journal     Volume:  59     ISSN:  2245-1919     ISO Abbreviation:  Dan Med J     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101576205     Medline TA:  Dan Med J     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  A4505     Citation Subset:  IM    
Bondehavevej 77, 2880 Bagsværd, Denmark.
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