Document Detail

Vitamin D deficiency and pregnancy: from preconception to birth.
MedLine Citation:
PMID:  20440696     Owner:  NLM     Status:  MEDLINE    
Vitamin D is important for bone health, as well as an increasing number of other health outcomes. Here we discuss the evidence relating to vitamin D in pregnancy, from preconception to the perinatal period. During pregnancy extra calcium required for fetal skeletal growth is attained by both maternal bone resorption and increased absorption from dietary sources, necessitating increased maternal vitamin D. Many women have low vitamin D status during pregnancy and may require supplementation, although optimal serum levels and intake required to achieve those levels is not yet well defined. Evidence from animal studies, with some supportive human evidence, suggests that fertility may be impaired in mothers with low vitamin D. During pregnancy, maintaining vitamin D and calcium levels may decrease the risks of pre-eclampsia, while gestational diabetes mellitus appears to be more common in those with low vitamin D status, although there is insufficient evidence of causality. The evidence in relation to increased risks of bacterial vaginosis and caesarean section similarly requires confirmation in carefully designed observational and experimental studies. This review outlines the emerging evidence that maternal vitamin D status during pregnancy is important for the health of the mother and offspring across a range of possible health outcomes.
Sharon Lewis; Robyn M Lucas; Jane Halliday; Anne-Louise Ponsonby
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  54     ISSN:  1613-4133     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-10     Completed Date:  2010-11-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1092-102     Citation Subset:  IM    
Public Health Genetics, Murdoch Childrens Research Institute, Royal Children's Hospital, Melbourne, Australia.
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MeSH Terms
Dietary Supplements
Infertility, Female / epidemiology
Pregnancy Complications* / drug therapy,  epidemiology,  physiopathology
Pregnancy Outcome
Vitamin D / metabolism,  physiology*,  therapeutic use
Vitamin D Deficiency* / drug therapy,  embryology,  epidemiology,  physiopathology
Reg. No./Substance:
1406-16-2/Vitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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