Document Detail


Vitamin D deficiency in pregnancy and gestational diabetes mellitus.
MedLine Citation:
PMID:  22717271     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: We examined the association of second-trimester maternal plasma 25-hydroxyvitamin D (25[OH]D) during pregnancy with gestational diabetes mellitus (GDM).
STUDY DESIGN: Among 1314 pregnant women who participated in Project Viva, a birth cohort study, we measured 25(OH)D levels at 26-28 weeks gestation during GDM screening using a 1-hour 50-g glucose challenge test.
RESULTS: We found 25(OH)D levels of <25 nmol/L in 44 of 1087 women (4.0%) with normal glucose tolerance, 9 of 159 women (5.7%) with impaired glucose tolerance, and 9 of 68 women (13.2%) with GDM. Analyses that were adjusted for sociodemographics, season, maternal body mass index, gestational weight gain, and dietary factors suggested that women with 25(OH)D levels of <25 vs ≥25 nmol/L may have higher odds of experiencing GDM (odds ratio, 2.2; 95% confidence interval, 0.8-5.5). Glucose levels after the glucose challenge test were associated inversely with 25(OH)D levels (P < .01).
CONCLUSION: Second-trimester 25(OH)D levels were associated inversely with glucose levels after 1-hour 50-g glucose challenge test; low 25(OH)D levels may be associated with increased risk of GDM.
Authors:
Heather H Burris; Sheryl L Rifas-Shiman; Ken Kleinman; Augusto A Litonjua; Susanna Y Huh; Janet W Rich-Edwards; Carlos A Camargo; Matthew W Gillman
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-06-01
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  207     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-03     Completed Date:  2012-11-13     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  182.e1-8     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 Mosby, Inc. All rights reserved.
Affiliation:
Department of Neonatology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Blood Glucose / analysis*
Diabetes, Gestational / blood*,  etiology*
Female
Humans
Pregnancy
Prospective Studies
Risk Factors
Vitamin D / analogs & derivatives*,  blood
Vitamin D Deficiency / blood*,  complications*
Grant Support
ID/Acronym/Agency:
K24 HL 06804/HL/NHLBI NIH HHS; K24 HL068041/HL/NHLBI NIH HHS; R01 HD034568/HD/NICHD NIH HHS; R01 HD034568/HD/NICHD NIH HHS; R01 HD064925/HD/NICHD NIH HHS; R01 HL064925/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D
Comments/Corrections
Comment In:
Am J Obstet Gynecol. 2012 Sep;207(3):e1-3   [PMID:  22939732 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Beyond cervical length: emerging technologies for assessing the pregnant cervix.
Next Document:  Comparative proteomic analysis of plasma from major depressive patients: identification of proteins ...