Document Detail


Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology.
MedLine Citation:
PMID:  21412501     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To examine the vitamin D status in patients with alcoholic cirrhosis compared to those with primary biliary cirrhosis.
METHODS: Our retrospective case series comprised 89 patients with alcoholic cirrhosis and 34 patients with primary biliary cirrhosis who visited our outpatient clinic in 2005 and underwent a serum vitamin D status assessment.
RESULTS: Among the patients with alcoholic cirrhosis, 85% had serum vitamin D levels below 50 nmol/L and 55% had levels below 25 nmol/L, as compared to 60% and 16% of the patients with primary biliary cirrhosis, respectively (P < 0.001). In both groups, serum vitamin D levels decreased with increasing liver disease severity, as determined by the Child-Pugh score.
CONCLUSION: Vitamin D deficiency in cirrhosis relates to liver dysfunction rather than aetiology, with lower levels of vitamin D in alcoholic cirrhosis than in primary biliary cirrhosis.
Authors:
Mikkel Malham; Søren Peter Jørgensen; Peter Ott; Jørgen Agnholt; Hendrik Vilstrup; Mette Borre; Jens F Dahlerup
Publication Detail:
Type:  Case Reports; Comparative Study; Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  17     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-03-17     Completed Date:  2011-07-21     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  922-5     Citation Subset:  IM    
Affiliation:
Department of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, DK-8000, Aarhus C, Denmark. mikkel.malham@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Humans
Liver / physiopathology*
Liver Cirrhosis, Alcoholic / blood,  complications*,  physiopathology
Liver Cirrhosis, Biliary / blood,  complications*,  physiopathology
Prevalence
Retrospective Studies
Risk Factors
Vitamin D / blood
Vitamin D Deficiency / epidemiology,  etiology*
Chemical
Reg. No./Substance:
1406-16-2/Vitamin D
Comments/Corrections

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