| Vitamin D and asthma. | |
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MedLine Citation:
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PMID: 21045696 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: asthma is a disease that continues to carry a significant health burden on humanity. Vitamin D is thought to play a role in many chronic diseases as it may possess immunomodulatory properties. This article will review the role of vitamin D regulation on the immune system and its potential implication in the pathophysiology of asthma. RECENT FINDINGS: vitamin D receptors are present on many cells in the body, specifically peripheral blood mononuclear cells. Vitamin D has been shown to regulate the balance of several pro-inflammatory and anti-inflammatory responses in the immune system. Studies have suggested that prenatal vitamin D intake has an effect on childhood wheezing and asthma. Additionally, vitamin D may play a role in asthma exacerbations, and recent evidence also suggests its importance in steroid resistant asthma. SUMMARY: vitamin D has a complex role on the immune system and its regulation of various aspects of immunity has allowed speculation on its potential role in asthma. However, the net effect of vitamin D on the immune system and its role in asthma still remains unanswered. More research needs to address the diagnostic and therapeutic implications vitamin D may have in the future of asthma management. |
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Authors:
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Garbo Mak; Nicola A Hanania |
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Publication Detail:
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Type: Editorial |
Journal Detail:
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Title: Current opinion in pulmonary medicine Volume: 17 ISSN: 1531-6971 ISO Abbreviation: Curr Opin Pulm Med Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9503765 Medline TA: Curr Opin Pulm Med Country: United States |
Other Details:
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Languages: eng Pagination: 1-5 Citation Subset: IM |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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