Document Detail


Vitamin D as adjunctive therapy in refractory pulmonary tuberculosis: a case report.
MedLine Citation:
PMID:  19434014     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Vitamin D regulates calcium homeostasis in the body and may play a major role in regulating immune responses to tuberculosis (TB). Pilot studies suggest that vitamin D supplementation may improve outcomes in pulmonary TB (PTB), but clinical evidence using vitamin D in TB treatment is limited. We present a case of vitamin D deficiency in a woman with refractory drug-susceptible PTB. Antituberculous therapy and the correction of vitamin D deficiency resulted in clinical and microbiologic improvement at month 13 of her treatment. The basis for vitamin D/TB interactions and a brief literature review are discussed. Data from controlled trials are needed to evaluate the efficacy of vitamin D as adjunctive TB therapy.
Authors:
Alexandra V Yamshchikov; Alawode Oladele; Michael K Leonard; Henry M Blumberg; Thomas R Ziegler; Vin Tangpricha
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Southern medical journal     Volume:  102     ISSN:  1541-8243     ISO Abbreviation:  South. Med. J.     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2011-03-01     Completed Date:  2011-04-22     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  649-52     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Female
Humans
Middle Aged
Tuberculosis, Pulmonary / complications,  drug therapy*
Vitamin D / therapeutic use*
Vitamin D Deficiency / complications,  drug therapy
Vitamins / therapeutic use*
Grant Support
ID/Acronym/Agency:
K23 AR054334/AR/NIAMS NIH HHS; K23 AR054334/AR/NIAMS NIH HHS; K23 AR054334-03/AR/NIAMS NIH HHS; K23 AR054334-04/AR/NIAMS NIH HHS; K24 RR023356/RR/NCRR NIH HHS; T32DK007298/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Vitamins; 1406-16-2/Vitamin D
Comments/Corrections

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