Document Detail


Vitamin D and Type 2 Diabetes.
MedLine Citation:
PMID:  23302127     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Based on increasing evidence from animal and human studies, vitamin D deficiency is now regarded as a potential risk factor for type 2 diabetes (T2D). Vitamin D is involved in the pathogenesis of pancreatic β-cell dysfunction, insulin resistance and systemic inflammation, conditions that contribute to the development of T2D. Vitamin D can affect the progress of this disease directly through the activation of its own receptor and indirectly via the regulation of calcium (Ca) homeostasis. Observational studies have revealed an inverse association between vitamin D deficiency and incident T2D. More double-blind randomized control studies that investigate the effects of vitamin D supplementation on insulin sensitivity, insulin secretion and the occurrence of T2D are needed. © 2013 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.
Authors:
Yan Xuan; Hong-Yan Zhao; Jian-Min Liu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-10
Journal Detail:
Title:  Journal of diabetes     Volume:  -     ISSN:  1753-0407     ISO Abbreviation:  J Diabetes     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101504326     Medline TA:  J Diabetes     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.
Affiliation:
Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, 197 Rui-jin Er Road.
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