| Vitamin D supplementation: a promising approach for the prevention and treatment of strokes. | |
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MedLine Citation:
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PMID: 20795935 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Vitamin D deficiency is highly prevalent due to lifestyle and environmental factors which limit sunlight induced vitamin D production in the skin. This "pandemic" of vitamin D deficiency is of concern because low levels of 25-hydroxyvitamin D (25[OH]D) have been associated with cardiovascular, musculoskeletal, infectious, autoimmune and malignant diseases. Epidemiological studies have largely but not consistently shown that vitamin D deficiency is a risk factor for strokes. This is supported by associations of low 25(OH)D levels with cerebrovascular risk factors, in particular with arterial hypertension. Vitamin D has also been shown to exert neuroprotective, neuromuscular and osteoprotective effects which may reduce cognitive and functional impairments in poststroke patients. Hence, the current literature favours the notion that vitamin D supplementation is a promising approach for the prevention and treatment of strokes but accurate data from interventional studies are missing. Randomized controlled trials are therefore urgently needed to evaluate whether vitamin D supplementation reduces the incidence of strokes and improves the outcome of poststroke patients. We do, however, believe that currently published data on the multiple health benefits of vitamin D and the easy safe and inexpensive way by which it can be supplemented already argue for the prevention and treatment of vitamin D deficiency in order to reduce stroke associated morbidity and mortality. |
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Authors:
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Stefan Pilz; Andreas Tomaschitz; Christiane Drechsler; Armin Zittermann; Jacqueline M Dekker; Winfried März |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current drug targets Volume: 12 ISSN: 1873-5592 ISO Abbreviation: Curr Drug Targets Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100960531 Medline TA: Curr Drug Targets Country: Netherlands |
Other Details:
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Languages: eng Pagination: 88-96 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Division of Endocrinology and Nuclear Medicine, Medical University of Graz, Austria. stefan.pilz@chello.at |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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