Document Detail

Vitamin D and subclinical cerebrovascular disease: the Atherosclerosis Risk in Communities brain magnetic resonance imaging study.
MedLine Citation:
PMID:  24861877     Owner:  NLM     Status:  MEDLINE    
IMPORTANCE: Vitamin D deficiency has been associated with hypertension, diabetes mellitus, and incident stroke. Little is known about the association between vitamin D and subclinical cerebrovascular disease.
OBJECTIVE: To examine the relationship of 25-hydroxyvitamin D (25[OH]D) levels with cerebrovascular abnormalities as assessed on brain magnetic resonance imaging (MRI) among participants of the Atherosclerosis Risk in Communities (ARIC) Brain MRI study.
DESIGN, SETTING, AND PARTICIPANTS: Participants were white and black adults aged 55 to 72 years with no history of clinical stroke who underwent a cerebral MRI at ARIC visit 3 (n = 1622) and a second cerebral MRI approximately 10 years later (n = 888).
EXPOSURES: The 25(OH)D level was measured by mass spectrometry at visit 3, with levels adjusted for calendar month and categorized using race-specific quartiles.
MAIN OUTCOMES AND MEASURES: The cross-sectional and prospective associations of 25(OH)D levels with white matter hyperintensities (WMHs) and MRI-defined infarcts were investigated using multivariable regression models.
RESULTS: The mean age of the participants was 62 years, 59.6% were women, and 48.6% were black. Lower 25(OH)D levels were not significantly associated with WMH score of severity, prevalent high-grade WMH score (≥3), or prevalent infarcts in cross-sectional, multivariable-adjusted models (all P > .05). Similarly, no significant prospective associations were found for lower 25(OH)D levels with change in WMH volume, incident high WMH score (≥3), or incident infarcts on the follow-up MRI, which occurred approximately 10 years later.
CONCLUSIONS AND RELEVANCE: A single measure of 25(OH)D was not cross-sectionally associated with WMH grade or prevalent subclinical infarcts and was not prospectively associated with WMH progression or subclinical brain infarcts seen on serial cerebral MRIs obtained approximately 10 years apart. These findings do not support optimizing vitamin D levels for brain health.
Erin D Michos; Kathryn A Carson; Andrea L C Schneider; Pamela L Lutsey; Li Xing; A Richey Sharrett; Alvaro Alonso; Laura H Coker; Myron Gross; Wendy Post; Thomas H Mosley; Rebecca F Gottesman
Related Documents :
22826387 - Mr/pet: a new challenge in hybrid imaging.
17281897 - Mri and image quantitation for drug assessment - growth effects of anabolic steroids an...
20930327 - New trends in mri of cartilage: advances and limitations in small animal studies.
18687277 - Imaging in osteoarthritis.
10080727 - Ct and mr imaging of the paranasal sinuses in cystic fibrosis. correlation with microbi...
22434627 - Functionalized single-walled carbon nanotubes containing traces of iron as new negative...
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  JAMA neurology     Volume:  71     ISSN:  2168-6157     ISO Abbreviation:  JAMA Neurol     Publication Date:  2014 Jul 
Date Detail:
Created Date:  2014-07-15     Completed Date:  2014-09-08     Revised Date:  2014-11-05    
Medline Journal Info:
Nlm Unique ID:  101589536     Medline TA:  JAMA Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  863-71     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
African Continental Ancestry Group / ethnology,  statistics & numerical data
Atherosclerosis / blood*,  diagnosis,  epidemiology
Brain Infarction / blood*,  diagnosis,  epidemiology
Cerebrovascular Disorders / blood*,  diagnosis,  epidemiology
Cross-Sectional Studies
European Continental Ancestry Group / ethnology,  statistics & numerical data
Magnetic Resonance Imaging*
Middle Aged
Mississippi / epidemiology
North Carolina / epidemiology
Prospective Studies
Residence Characteristics*
Severity of Illness Index
Vitamin D / analogs & derivatives*,  blood
Grant Support
Reg. No./Substance:
1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Bactericidal Activity of Partially Oxidized Nanodiamonds.
Next Document:  JAK2/STAT3 targeted therapy suppresses tumor invasion via disruption of the EGFRvIII/JAK2/STAT3 axis...