| Vitamin D Status Affects Strength Gains in Older Adults Supplemented With a Combination of {beta}-Hydroxy-{beta}-Methylbutyrate, Arginine, and Lysine: A Cohort Study. | |
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MedLine Citation:
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PMID: 21807930 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Older adults supplemented for 1 year with β-hydroxy-β-methylbutyrate, arginine, and lysine (HMB/ARG/LYS) were previously shown to have significant gains in fat-free mass (FFM) but not muscular strength. OBJECTIVE: Recently, increasing levels of serum vitamin D have been associated with an increase in muscle function, particularly in the elderly. To determine if vitamin D status may have limited strength gain in participants supplemented with HMB/ARG/LYS, the authors performed post hoc analysis of strength based on the participants' vitamin D status. METHODS: Elderly (age 76.0 ± 1.6 years) adults were recruited for a double-blinded, controlled study and were randomly assigned to either an isonitrogenous control (n = 37) or HMB/ARG/LYS (n = 40) for the yearlong study. Participants were further segregated based on their vitamin D status of either <30 or ≥30 ng 25OH-vitD(3)/mL serum, and an analysis was performed on the 4 cohorts. RESULTS: Regardless of vitamin D status, HMB/ARG/LYS resulted in significantly increased FFM (P < .02), but only in those with vitamin D status ≥30 ng 25OH-vitD(3)/mL was there a significant increase in strength with HMB/ARG/LYS (P < .01). Control-supplemented participants, regardless of vitamin D status, and the HMB/ARG/LYS-supplemented participants with vitamin D status <30 ng 25OH-vitD(3) failed to show improvements in strength. CONCLUSIONS: The nutrient cocktail of HMB/ARG/LYS alone was effective in increasing muscle mass regardless of vitamin D status, but accompanying strength increases were observed only when participants also had adequate vitamin D status indicating a synergistic effect between the HMB/ARG/LYS and vitamin D. (JPEN J Parenter Enteral Nutr. XXXX;XX:xx-xx). |
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Authors:
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John C Fuller; Shawn Baier; Paul Flakoll; Steven L Nissen; Naji N Abumrad; John A Rathmacher |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-1 |
Journal Detail:
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Title: JPEN. Journal of parenteral and enteral nutrition Volume: - ISSN: 0148-6071 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7804134 Medline TA: JPEN J Parenter Enteral Nutr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Metabolic Technologies Inc. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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