Document Detail


Vitamin D and Pregnancy: Skeletal Effects, Nonskeletal Effects, and Birth Outcomes.
MedLine Citation:
PMID:  22623177     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The function and requirement of vitamin D during pregnancy for both mother and fetus have remained a mystery. This fact was highlighted by The Cochrane Review in 2000, which reported a lack of randomized controlled trials (RCTs) with respect to vitamin D requirements during pregnancy. Unfortunately, during the past decade only a single RCT has been performed with respect to vitamin D requirements during pregnancy. In this review we will discuss vitamin D metabolism during pregnancy as well as the consequences of vitamin D deficiency on skeletal, nonskeletal, and birth outcomes using birth observational data and data from our recent RCT. New RCT data strongly support previous observational studies in that improving nutritional vitamin D status will improve birth outcomes. The new RCT data indicate that 4,000 IU/day vitamin D(3) during pregnancy will "normalize" vitamin D metabolism and improve birth outcomes including primary cesarean section and comorbidities of pregnancy with no risk of side effects.
Authors:
Bruce W Hollis; Carol L Wagner
Related Documents :
2107047 - The phakomatoses as paracrine growth disorders (paracinopathies).
2485137 - Monitoring of murine feto-placental growth by pregnancy-specific serum proteins in an e...
18279787 - Regulation of fetal growth: consequences and impact of being born small.
19854107 - Pathological assessment of intrauterine growth restriction.
21793087 - Aberrant right subclavian artery (arsa). incidence and correlation with other markers o...
2107047 - The phakomatoses as paracrine growth disorders (paracinopathies).
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-24
Journal Detail:
Title:  Calcified tissue international     Volume:  -     ISSN:  1432-0827     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905481     Medline TA:  Calcif Tissue Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Pediatrics, Darby Children's Research Institute, Medical University of South Carolina, 173 Ashley Ave., Room 313, Charleston, SC, 29425, USA, hollisb@musc.edu.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The ovarian cancer-derived secretory/releasing proteome: a repertoire of tumor markers.
Next Document:  Incidental Findings with Dual-Energy X-Ray Absorptiometry: Spectrum of Possible Diagnoses.