| Vitamin D Levels and Risk of Acute Exacerbations of Chronic Obstructive Pulmonary Disease: a Prospective Cohort Study. | |
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MedLine Citation:
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PMID: 22077070 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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RATIONALE: Low blood levels of 25-hyroxyvitamin D (25[OH]D) have been associated with a higher risk of respiratory infections in general populations and higher risk of exacerbations of lung disease in asthmatics. We hypothesized that low blood levels of 25(OH)D in patients with chronic obstructive pulmonary disease (COPD) would be associated with an increased risk of acute exacerbations of COPD (AECOPD). OBJECTIVES: To determine if baseline 25(OH)D levels relate to subsequent AECOPD in a cohort of patients at high risk for AECOPD. METHODS AND MEASUREMENTS: Plasma 25(OH)D was measured at baseline in 973 participants on entry to a one-year study designed to determine if daily azithromycin decreased the incidence of AECOPD. Relationships between baseline 25(OH)D and AECOPD over one year were analyzed with time to first AECOPD as the primary outcome and exacerbation rate as the secondary outcome. MAIN RESULTS: In this largely Caucasian (85%) sample of North American patients with severe COPD (mean FEV1 1.12L, 40% of predicted), mean 25(OH)D was 25.7 ± 12.8 ng/mL. 33.1% of participants were Vitamin D insufficient (≥20 ng/mL but <30 ng/mL), 32.0% were Vitamin D deficient (<20 ng/mL) and 8.4% had severe vitamin D deficiency (<10 ng/mL). Baseline 25(OH)D levels had no relationship to time to first AECOPD nor AECOPD rates. CONCLUSIONS: In patients with severe COPD, baseline 25(OH)D levels are not predictive of subsequent AECOPD. |
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Authors:
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Ken M Kunisaki; Dennis E Niewoehner; John E Connett; |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-11-10 |
Journal Detail:
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Title: American journal of respiratory and critical care medicine Volume: - ISSN: 1535-4970 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-11-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421642 Medline TA: Am J Respir Crit Care Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Pulmonary (111N), Minneapolis VA Medical Center, One Veterans Drive, Minneapolis, Minnesota, 55417, United States; Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Minnesota, Minneapolis, Minnesota, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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