| Vitamin D Intake and Status Are Associated with Lower Prevalence of Metabolic Syndrome in U.S. Adults: National Health and Nutrition Examination Surveys 2003-2006. | |
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MedLine Citation:
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PMID: 22793651 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Background: Previous reports have shown that metabolic syndrome and some metabolic syndrome components are associated with serum 25-hydroxyvitamin D [25(OH)D]. Methods: Using the National Health and Nutrition Examination Surveys (NHANES), 2003-2006, we evaluated the associations of vitamin D intake (n=3543) and vitamin D status [25(OH)D; n=3529], with the prevalence of metabolic syndrome and its components in adults 20 years and older. Exclusion criteria included nonfasted subjects, those pregnant and/or lactating, and, for intake analyses, those with unreliable 24-h recall records. Subjects were separately classified into quartiles of vitamin D intake (both including and excluding supplements) and serum 25(OH)D. Logistic regression was used to determine odds ratios (OR) for metabolic syndrome after adjusting for multiple confounders. Results: Those in the highest quartile of serum 25(OH)D had 60% lower odds for metabolic syndrome as compared to those in the lowest quartile [OR=0.40; 95% confidence interval (CI) 0.27, 0.59]. Elevated waist circumference (OR=0.57; 95% CI 0.39, 0.84), low high-density lipoprotein cholesterol (HDL-C) (OR=0.54; 95% CI 0.39, 0.75), and high homeostasis model assessment of insulin resistance (HOMA-IR) (OR=0.40; 95% CI 0.29, 0.55) were the main components associated with serum 25(OH)D. Compared with the lowest vitamin D intake quartile (excluding supplements), those in the highest intake quartile had 28% lower odds for metabolic syndrome (OR=0.72; 95% CI 0.58, 0.90). No components of metabolic syndrome were significantly associated with dietary intake of vitamin D with supplements included or excluded. Conclusions: We conclude that higher 25(OH)D, and, to a lesser degree, greater dietary vitamin D intake, are associated with reduced prevalence of metabolic syndrome. |
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Authors:
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Kevin C Maki; Victor L Fulgoni; Debra R Keast; Tia M Rains; Keigan M Park; Martyn R Rubin |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-13 |
Journal Detail:
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Title: Metabolic syndrome and related disorders Volume: - ISSN: 1557-8518 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101150318 Medline TA: Metab Syndr Relat Disord Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1 Biofortis Clinical Research , Addison, Illinois. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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