Document Detail


Vitamin D intake needed to maintain target serum 25-hydroxyvitamin D concentrations in participants with low sun exposure and dark skin pigmentation is substantially higher than current recommendations.
MedLine Citation:
PMID:  20053937     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cutaneous cholecalciferol synthesis has not been considered in making recommendations for vitamin D intake. Our objective was to model the effects of sun exposure, vitamin D intake, and skin reflectance (pigmentation) on serum 25-hydroxyvitamin D (25[OH]D) in young adults with a wide range of skin reflectance and sun exposure. Four cohorts of participants (n = 72 total) were studied for 7-8 wk in the fall, winter, spring, and summer in Davis, CA [38.5 degrees N, 121.7 degrees W, Elev. 49 ft (15 m)]. Skin reflectance was measured using a spectrophotometer, vitamin D intake using food records, and sun exposure using polysulfone dosimeter badges. A multiple regression model (R(2) = 0.55; P < 0.0001) was developed and used to predict the serum 25(OH)D concentration for participants with low [median for African ancestry (AA)] and high [median for European ancestry (EA)] skin reflectance and with low [20th percentile, approximately 20 min/d, approximately 18% body surface area (BSA) exposed] and high (80th percentile, approximately 90 min/d, approximately 35% BSA exposed) sun exposure, assuming an intake of 200 iu/d (5 ug/d). Predicted serum 25(OH)D concentrations for AA individuals with low and high sun exposure in the winter were 24 and 42 nmol/L and in the summer were 40 and 60 nmol/L. Corresponding values for EA individuals were 35 and 60 nmol/L in the winter and in the summer were 58 and 85 nmol/L. To achieve 25(OH)D > or =75 nmol/L, we estimate that EA individuals with high sun exposure need 1300 iu/d vitamin D intake in the winter and AA individuals with low sun exposure need 2100-3100 iu/d year-round.
Authors:
Laura M Hall; Michael G Kimlin; Pavel A Aronov; Bruce D Hammock; James R Slusser; Leslie R Woodhouse; Charles B Stephensen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2010-01-06
Journal Detail:
Title:  The Journal of nutrition     Volume:  140     ISSN:  1541-6100     ISO Abbreviation:  J. Nutr.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-22     Completed Date:  2010-03-25     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  542-50     Citation Subset:  IM    
Affiliation:
Nutrition Department, University of California, Davis, CA, 95616, USA. lauhall@calpoly.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
African Americans
California
Diet Records
Dose-Response Relationship, Drug
European Continental Ancestry Group
Female
Humans
Male
Nutritional Requirements
Seasons
Skin Pigmentation / physiology*
Sunlight
Vitamin D / administration & dosage*,  analogs & derivatives*,  blood,  pharmacology*
Young Adult
Grant Support
ID/Acronym/Agency:
P01 ES011269/ES/NIEHS NIH HHS; P42 ES004699/ES/NIEHS NIH HHS; P60MD0222/MD/NIMHD NIH HHS; T32 ES007059/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
1406-16-2/Vitamin D; 64719-49-9/25-hydroxyvitamin D
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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